nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2012-16-2-79-83nefr-581Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКИЕ ИССЛЕДОВАНИЯORIGINAL ARTICLES. CLINICAL INVESTIGATIONSЗНАЧЕНИЕ СЕЗОННОГО ФАКТОРА В ОЦЕНКЕ СТАТУСА ВИТАМИНА D У ПАЦИЕНТОВ С РАННИМИ СТАДИЯМИ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕКSIGNIFICANCE OF SEASONAL FACTOR IN EVALUATION OF VITAMIN D STATUS AT PATIENTS WITH EARLY STAGES OF CHRONIC KIDNEY DISEASEВолковМ. М.VolkovM. M.

Кафедра пропедевтики внутренних болезней

197022, Санкт-Петербург, ул. Л. Толстого, д. 17, тел.:8-812-234-01-65

vmm58@mail.ruРафрафиХ.RafrafiH.

Кафедра пропедевтики внутренних болезней

СмирновА. В.SmirnovA. V.

Кафедра пропедевтики внутренних болезней

Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.ПавловаРоссия2012100220121627983Copyright © Волков М.М., Рафрафи Х., Смирнов А.В., 20122012Волков М.М., Рафрафи Х., Смирнов А.В.Volkov M.M., Rafrafi H., Smirnov A.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/581

ЦЕЛЬ ИССЛЕДОВАНИЯ: определить влияние сезонного фактора на статус витамина D (ВД) у пациентов с ранними стадиями хронической болезни почек (ХБП). ПАЦИЕНТЫ И МЕТОДЫ. Обследованы 94 пациентов с ХБП 1–4 стадии, м/ж – 45/49, 60,1±12,6 года, в большинстве с диабетической нефропатией (91,2 %). Помимо обычных показателей, иммуноферментным методом были определены 25(OH)D и 1,25(OH)2D. РЕЗУЛЬТАТЫ. Дефицит 25(OH)D (уровень ниже 30 нмоль/л) выявлен у 14,9% пациентов, недостаточность (30–75 нмоль/л) – у 55,4% и оптимальные значения (выше 75 нмоль/л) – у 29,7%. В 63,8% случаев обнаружен дефицит 1,25(OH)2D (концентрация в сыворотке ниже 53 пмоль/л). Уровень 25(OH)D, определенный у пациентов осенью (n=30), был выше, чем весной (n=64; р=0,002). По данным множественного регрессионного анализа, выявлена также тенденция сезонных изменений значений 1,25(OH)2D (p=0,09), обусловленных колебаниями уровня 25(OH)D. ЗАКЛЮЧЕНИЕ. Недостаточность и дефицит 25(OH)D часто наблюдаются у пациентов с ХБП 1–4 стадии. Уровень 25(OH)D имеет значительные сезонные колебания, что приводит к некоторым сезонным изменениям концентрации 1,25(OH)2D.

AIM OF RESEARCH: to define the esimate of seasonal factor on vitamin D (VD) status in patients with early stages of chronic kidney disease (CKD). PATIENTS AND METHODS. There were examined 94 patients with CKD of 1-4 stage, male/female – 45/49, 60,1±12,6 years mainly with diabetic nephropathy (91,2%). Besides usual factors by immunoenzyme method were estimated 25(OH)D and 1,25(OH)2D. RESULTS. Defficiency of 25(OH)D (level is lower 30 nM/l) was diagnosed at 14,9% of patients, insufficiency (30-75 nM/l) – at 55,4% and optimal value (higher than 75 nM/l) – at 29,7%. In 63,8% of cases insufficiency of 1,25(OH)2D was defined (concentration in serum lower than 53nM/l). In autumn level of 25(OH)D (n=30) was higher than in spring (n=64, p=0,002). According to data of multiple regression analysis was defined tendention of value seasonal variations of 1,25(OH)2D (p=0,09) due to escurtion of 25(OH)D. CONCLUSION. Insufficiency and defficiency of 25(OH)D are regular at patients with chronic kidney disease of 1-4 stage. Level of 25(OH)D have serious seasonal variations which provide some seasonal variations of 1,25(OH)2D concentration.

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The authors declare that there are no conflicts of interest present.