nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2006-10-2-110-117nefr-589Research ArticleПРОГРАММА НЕПРЕРЫВНОГО ПОСЛЕДИПЛОМНОГО ОБРАЗОВАНИЯ ПО НЕФРОЛОГИИPROGRAM ON CONTINUOUS POSTGRADUATE EDUCATION ON NEPHROLOGYУРЕМИЧЕСКИЙ ЗУД У БОЛЬНЫХ НА ЗАМЕСТИТЕЛЬНОЙ ПОЧЕЧНОЙ ТЕРАПИИUREMIC PRURITUS IN PATIENTS ON RENAL REPLACEMENT THERAPYВолковМ. М.VolkovM. M.

кафедра пропедевтики внутренних болезней, научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова

ДобронравовВ. А.DobronravovV. A.

кафедра пропедевтики внутренних болезней, научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова

Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаRussian Federation200610022006102110117Copyright © Волков М.М., Добронравов В.А., 20062006Волков М.М., Добронравов В.А.Volkov M.M., Dobronravov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/589

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уремический зудгемодиализлечениеuremic pruritushemodialysistreatmentReferencesMoses S. Pruritus. Am Fam Physician2003; 68: 1135-1142,1145-1146Moses S. Pruritus. Am Fam Physician2003; 68: 1135-1142,1145-1146Robertson KE, Mueller BA. Uremic pruritus. Am J Health Syst Pharm 1996; 53: 2159-2170Robertson KE, Mueller BA. Uremic pruritus. Am J Health Syst Pharm 1996; 53: 2159-2170Szepietowski JC, Sikora M, Kusztal M et al. Uremic pruritus: a clinical study of maintenance hemodialysis patients. J Dermatol 2002; 29(10): 621-627Szepietowski JC, Sikora M, Kusztal M et al. Uremic pruritus: a clinical study of maintenance hemodialysis patients. J Dermatol 2002; 29(10): 621-627Stahle-Backdahl M. Uremic pruritus. Clinical and experimental studies. Acta Derm Venereol Suppl(Stockh) 1989; 145: 1-38Stahle-Backdahl M. Uremic pruritus. Clinical and experimental studies. Acta Derm Venereol Suppl(Stockh) 1989; 145: 1-38Gilchrest BA, Stern RS, Steinman TI. Clinical features of pruritus among patients undergoing maintenance hemodialysis. Arch Dermatol 1982; 118(3): 154-156Gilchrest BA, Stern RS, Steinman TI. Clinical features of pruritus among patients undergoing maintenance hemodialysis. Arch Dermatol 1982; 118(3): 154-156Stahle-Backdahl M, Wahlgren CF, Hagermark O. Computerized recording of itch in patients on maintenance hemodialysis. Acta Derm Venereol 1989; 69(5): 410-414Stahle-Backdahl M, Wahlgren CF, Hagermark O. Computerized recording of itch in patients on maintenance hemodialysis. Acta Derm Venereol 1989; 69(5): 410-414Zucker I, Yosipovitch G, David M et al. Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. J Am Acad Dermatol 2003; 49(5): 842-846Zucker I, Yosipovitch G, David M et al. Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease. J Am Acad Dermatol 2003; 49(5): 842-846Mettang T, Pauli-Magnus C, Alscher DM. Uraemic pruritus—new perspectives and insights from recent trials. Nephrol Dial Transplant 2002; 17: 1558-1563Mettang T, Pauli-Magnus C, Alscher DM. Uraemic pruritus—new perspectives and insights from recent trials. Nephrol Dial Transplant 2002; 17: 1558-1563Balaskas EV, Bamihas GI, Karamouzis M et al. Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. Nephron 1998; 78(4): 395-402Balaskas EV, Bamihas GI, Karamouzis M et al. Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients. Nephron 1998; 78(4): 395-402Balaskas EV, Chu M, Uldall RP et al. Pruritus in continuous ambulatory peritoneal dialysis and hemodialysis patients. Perit Dial Int 1993; [13 Suppl 2]: S527-532Balaskas EV, Chu M, Uldall RP et al. Pruritus in continuous ambulatory peritoneal dialysis and hemodialysis patients. Perit Dial Int 1993; [13 Suppl 2]: S527-532Adams J. Uremic pruritus related to duration, haemodialysis type in renal failure. J Dermatol 2002; 29(10): 621-627Adams J. Uremic pruritus related to duration, haemodialysis type in renal failure. J Dermatol 2002; 29(10): 621-627Chou FF, H. J., Huang SC, Sheen-Chen SM. A study on pruritus after parathyroidectomy for secondary hyperparathyroidism. J Am Coll Surg 2000; 190(1): 65-70Chou FF, H. J., Huang SC, Sheen-Chen SM. A study on pruritus after parathyroidectomy for secondary hyperparathyroidism. J Am Coll Surg 2000; 190(1): 65-70Rashed A, Fahmi M, El Sayed M et al. Effectiveness of surgical parathyroidectomy for secondary hyperparathyroidism in renal dialysis patients in Qatar. Transplant Proc 2004; 36(6): 1815-1817Rashed A, Fahmi M, El Sayed M et al. Effectiveness of surgical parathyroidectomy for secondary hyperparathyroidism in renal dialysis patients in Qatar. Transplant Proc 2004; 36(6): 1815-1817Cohen EP, Russell TJ, Garancis JC. Mast cells and calcium in severe uremic itching. Am J Med Sci 1992; 303(6): 360-365Cohen EP, Russell TJ, Garancis JC. Mast cells and calcium in severe uremic itching. Am J Med Sci 1992; 303(6): 360-365Cho YL, Liu HN, Huang TP, Tarng DC. Uremic pruritus: roles of parathyroid hormone and substance P. J Am Acad Dermatol 1997; 36: 538–543Cho YL, Liu HN, Huang TP, Tarng DC. Uremic pruritus: roles of parathyroid hormone and substance P. J Am Acad Dermatol 1997; 36: 538–543Momose A, Kudo S, Sato M et al. Calcium ions are abnormally distributed in the skin of haemodialysis patients with uraemic pruritus. Nephrol Dial Transplant 2004; 19(8): 2061-2066Momose A, Kudo S, Sato M et al. Calcium ions are abnormally distributed in the skin of haemodialysis patients with uraemic pruritus. Nephrol Dial Transplant 2004; 19(8): 2061-2066Mesic E, Tabakovic M, Habul V et al. Clinical characteristics of uremic pruritus in hemodialysis patients. Acta Med Croatica 2004; 58(5): 377-380Mesic E, Tabakovic M, Habul V et al. Clinical characteristics of uremic pruritus in hemodialysis patients. Acta Med Croatica 2004; 58(5): 377-380Blachley JD, Blankenship DM, Menter A et al. Uremic pruritus: skin divalent ion content and response to ultraviolet phototherapy. Am J Kidney Dis 1985; 5(5): 237-241Blachley JD, Blankenship DM, Menter A et al. Uremic pruritus: skin divalent ion content and response to ultraviolet phototherapy. Am J Kidney Dis 1985; 5(5): 237-241Friga V, Linos A, Linos DA. Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients? Nephron 1997; 75(1): 48-53Friga V, Linos A, Linos DA. Is aluminum toxicity responsible for uremic pruritus in chronic hemodialysis patients? Nephron 1997; 75(1): 48-53Hiroshige K, Kabashima N, Takasugi M et al. Optimal dialysis improves uremic pruritus. Am J Kidney Dis 1995; 25(3): 413-419Hiroshige K, Kabashima N, Takasugi M et al. Optimal dialysis improves uremic pruritus. Am J Kidney Dis 1995; 25(3): 413-419Subach RA, Marx MA. Evaluation of uremic pruritus at an outpatient hemodialysis unit. Ren Fail 2002; 24(5): 609-614Subach RA, Marx MA. Evaluation of uremic pruritus at an outpatient hemodialysis unit. Ren Fail 2002; 24(5): 609-614Masi CM, Cohen EP. Dialysis efficacy and itching in renal failure. Nephron 1992; 62:257-261Masi CM, Cohen EP. Dialysis efficacy and itching in renal failure. Nephron 1992; 62:257-261Jakic M. Does uremic pruritus in hemodialyzed patients disappear only with replacement therapy? Lijec Vjesn 1999; 121(4-5): 118-122Jakic M. Does uremic pruritus in hemodialyzed patients disappear only with replacement therapy? Lijec Vjesn 1999; 121(4-5): 118-122Dimkovic N, Djukanovic L, Radmilovic A et al. Uremic pruritus and skin mast cells. Nephron 1992; 61(1): 5-9Dimkovic N, Djukanovic L, Radmilovic A et al. Uremic pruritus and skin mast cells. Nephron 1992; 61(1): 5-9Rollino C, G. M., Piccoli G, Puiatti P et al. What is the role of sensitization in uremic pruritus? An allergologic study. Nephron 1991; 57(3): 319-322Rollino C, G. M., Piccoli G, Puiatti P et al. What is the role of sensitization in uremic pruritus? An allergologic study. Nephron 1991; 57(3): 319-322Stahle-Backdahl M. Stratum corneum hydration in patients undergoing maintenance hemodialysis. Acta Derm Venereol 1988; 68(6): 531-534Stahle-Backdahl M. Stratum corneum hydration in patients undergoing maintenance hemodialysis. Acta Derm Venereol 1988; 68(6): 531-534De Marchi S, Cecchin E, Villalta D et al. Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. N Engl J Med 1992; 326: 969-974De Marchi S, Cecchin E, Villalta D et al. Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. N Engl J Med 1992; 326: 969-974Akhyani M, Ganji M-R, Samadi N et al. Pruritus in hemodialysis patients. BMC Dermatology 2005; 5: 7Akhyani M, Ganji M-R, Samadi N et al. Pruritus in hemodialysis patients. BMC Dermatology 2005; 5: 7Jedras M, Zakrzewska-Pniewska B, Wardyn K et al. Uremic neuropathy—II. Is pruritus in dialyzed patients related to neuropathy? Pol Arch Med Wewn 1998; 99(6): 462-469Jedras M, Zakrzewska-Pniewska B, Wardyn K et al. Uremic neuropathy—II. Is pruritus in dialyzed patients related to neuropathy? Pol Arch Med Wewn 1998; 99(6): 462-469Zakrzewska-Pniewska B, Jedras M. Is pruritus in chronic uremic patients related to peripheral somatic and autonomic neuropathy? Study by R-R interval variation test (RRIV) and by sympathetic skin response (SSR). Neurophysiol Clin 2001; 31(3): 181-193.Zakrzewska-Pniewska B, Jedras M. Is pruritus in chronic uremic patients related to peripheral somatic and autonomic neuropathy? Study by R-R interval variation test (RRIV) and by sympathetic skin response (SSR). Neurophysiol Clin 2001; 31(3): 181-193.Hung KY, Shyu RS, Tsai TJ et al. Viral hepatitis infection should be considered for evaluating uremic pruritus in continuous ambulatory peritoneal dialysis patients. Blood Purif 1998; 16(3): 147-153Hung KY, Shyu RS, Tsai TJ et al. Viral hepatitis infection should be considered for evaluating uremic pruritus in continuous ambulatory peritoneal dialysis patients. Blood Purif 1998; 16(3): 147-153Sanada S, Kuze M, Yoshida O. Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels. Hinyokika Kiyo 1987; 33(12): 1955-1960Sanada S, Kuze M, Yoshida O. Beneficial effect of zinc supplementation on pruritus in hemodialysis patients with special reference to changes in serum histamine levels. Hinyokika Kiyo 1987; 33(12): 1955-1960Twycross R, Greaves MW, Handwerker H et al. Itch: scratching more than the surface. Q J Med 2003; 96: 7-26Twycross R, Greaves MW, Handwerker H et al. Itch: scratching more than the surface. Q J Med 2003; 96: 7-26Mettang T, Fritz P, Weber J et al. Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. Clin Nephrol 1990; 34(3): 136-141Mettang T, Fritz P, Weber J et al. Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. Clin Nephrol 1990; 34(3): 136-141Weisshaar E, Dunker N, Domrose U et al. Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy. Clinical Nephrology 2003; 59(2): 124-129Weisshaar E, Dunker N, Domrose U et al. Plasma serotonin and histamine levels in hemodialysis-related pruritus are not significantly influenced by 5-HT3 receptor blocker and antihistaminic therapy. Clinical Nephrology 2003; 59(2): 124-129Gilchrest BA, Rowe JW, Brown RS et al. Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action. Ann Intern Med 1979; 91(1): 17-21Gilchrest BA, Rowe JW, Brown RS et al. Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action. Ann Intern Med 1979; 91(1): 17-21Silva SR, Viana PC, Lugon NV et al. Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. Nephron 1994; 67(3): 270-273Silva SR, Viana PC, Lugon NV et al. Thalidomide for the treatment of uremic pruritus: a crossover randomized double-blind trial. Nephron 1994; 67(3): 270-273Peer G. Naltrexone for Uremic Pruritus. Randomised crossover trial of naltrexone in uraemic pruritus. Lancet 1996; 348: 1552Peer G. Naltrexone for Uremic Pruritus. Randomised crossover trial of naltrexone in uraemic pruritus. Lancet 1996; 348: 1552Pauli-Magnus C, Mikus G, Alscher DM et al. Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. Am Soc Nephrol 2000; 11(3): 514-519Pauli-Magnus C, Mikus G, Alscher DM et al. Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. Am Soc Nephrol 2000; 11(3): 514-519Okada K, Matsumoto K. Effect of skin care with an emollient containing a high water content on mild uremic pruritus. Ther Apher Dial 2004; 8(5): 419-422Okada K, Matsumoto K. Effect of skin care with an emollient containing a high water content on mild uremic pruritus. Ther Apher Dial 2004; 8(5): 419-422Francos GC, Kauh YC, Gittlen SD et al. Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. Int J Dermatol 1991; 30(12): 884-889Francos GC, Kauh YC, Gittlen SD et al. Elevated plasma histamine in chronic uremia. Effects of ketotifen on pruritus. Int J Dermatol 1991; 30(12): 884-889Legroux-Crespel E, Cledes J, Misery L. A comparative study on the effects of naltrexone and loratadine on uremic pruritus. Dermatology 2004; 208(4): 326-330Legroux-Crespel E, Cledes J, Misery L. A comparative study on the effects of naltrexone and loratadine on uremic pruritus. Dermatology 2004; 208(4): 326-330Gilchrest BA, Rowe JW, Brown RS et al. Relief of uremic pruritus with ultraviolet phototherapy. N Engl J Med 1977 21; 297(3): 136-138Gilchrest BA, Rowe JW, Brown RS et al. Relief of uremic pruritus with ultraviolet phototherapy. N Engl J Med 1977 21; 297(3): 136-138Lubach D, Kock BW. Treatment of severe pruritus in dialysis patients with selective UV-phototherapy (SUP). Fortschr Med 1983; 101(46): 2125-2128Lubach D, Kock BW. Treatment of severe pruritus in dialysis patients with selective UV-phototherapy (SUP). Fortschr Med 1983; 101(46): 2125-2128Schultz BC, Roenigk HH. Uremic pruritus treated with ultraviolet light. JAMA 1980; 243(18): 1836-1837Schultz BC, Roenigk HH. Uremic pruritus treated with ultraviolet light. JAMA 1980; 243(18): 1836-1837Ada S, Seckin D, Budakoglu I et al. Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study. J Am Acad Dermatol 2005; 53(1): 149-151Ada S, Seckin D, Budakoglu I et al. Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study. J Am Acad Dermatol 2005; 53(1): 149-151Tan JK, Haberman HF, Coldman AJ. Identifying effective treatment for uremic pruritus. J Am Acad Dermatol 1991; 25: 811-818Tan JK, Haberman HF, Coldman AJ. Identifying effective treatment for uremic pruritus. J Am Acad Dermatol 1991; 25: 811-818Gilchrest BA. Ultraviolet phototherapy of uremic pruritus. Int J Dermatol 1979; 18(9): 741-748Gilchrest BA. Ultraviolet phototherapy of uremic pruritus. Int J Dermatol 1979; 18(9): 741-748Giovannetti S, Barsotti G, Cupisti A et al. Oral activated charcoal in patients with uremic pruritus. Nephron 1995; 70(2): 193-196Giovannetti S, Barsotti G, Cupisti A et al. Oral activated charcoal in patients with uremic pruritus. Nephron 1995; 70(2): 193-196Мухин А. Исследование действия налтрексона у больных с уремическим зудом. РМЖ 1997; 5(16)Мухин А. Исследование действия налтрексона у больных с уремическим зудом. РМЖ 1997; 5(16)Sorbera, LA, Castaner J, Leeson PA. Nalfurafine hydrochloride. Drugs Fut 2003; 28(3): 237Sorbera, LA, Castaner J, Leeson PA. Nalfurafine hydrochloride. Drugs Fut 2003; 28(3): 237Tokgoz B, Ata A, Spanolu M et al. Effects of oral granisetron treatment on uremic pruritus. Turk J Med Sci 2005; 35: 93-97Tokgoz B, Ata A, Spanolu M et al. Effects of oral granisetron treatment on uremic pruritus. Turk J Med Sci 2005; 35: 93-97Ashmore SD, Jones CH, Newstead CG et al. Ondansetron therapy for uremic pruritus in hemodialysis patients. Am J Kidney Dis 2000; 35(5): 827-831Ashmore SD, Jones CH, Newstead CG et al. Ondansetron therapy for uremic pruritus in hemodialysis patients. Am J Kidney Dis 2000; 35(5): 827-831Weisshaar E, Ziethen B, Gollnick H. Lack of efficacy of topical capsaicin in serotonin-induced itch. Skin Pharmacol Appl Skin Physiol. 2000; 13(1): 1-8Weisshaar E, Ziethen B, Gollnick H. Lack of efficacy of topical capsaicin in serotonin-induced itch. Skin Pharmacol Appl Skin Physiol. 2000; 13(1): 1-8Duque MI, Yosipovitch G, Fleischer AB et al. Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study. J Am Acad Dermatol 2005; 52(3 Pt 1): 519-521Duque MI, Yosipovitch G, Fleischer AB et al. Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study. J Am Acad Dermatol 2005; 52(3 Pt 1): 519-521Yoshimoto-Furuie K, Yoshimoto K, Tanaka T et al. Effects of oral supplementation with evening primrose oil for 6 weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients. Nephron 1999; 81(2): 151-159Yoshimoto-Furuie K, Yoshimoto K, Tanaka T et al. Effects of oral supplementation with evening primrose oil for 6 weeks on plasma essential fatty acids and uremic skin symptoms in hemodialysis patients. Nephron 1999; 81(2): 151-159Ha HC. Effect of aromatherapy on skin xerosis and pruritus in patients undergoing maintenance hemodialysis. J Korean Acad Nurs 1999; 29(6): 1284-1293Ha HC. Effect of aromatherapy on skin xerosis and pruritus in patients undergoing maintenance hemodialysis. J Korean Acad Nurs 1999; 29(6): 1284-1293Manenti L, Vaglio A, Costantino E et al. Gabapentin in the treatment of uremic itch: An index case and a pilot evaluation. J Nephrol 2005; 18(1): 86-91Manenti L, Vaglio A, Costantino E et al. Gabapentin in the treatment of uremic itch: An index case and a pilot evaluation. J Nephrol 2005; 18(1): 86-91Duo LJ. Electrical needle therapy of uremic pruritus. Nephron 1987; 47(3): 179-183Duo LJ. Electrical needle therapy of uremic pruritus. Nephron 1987; 47(3): 179-183Stockard H. Successful treatment of uremic pruritus: the acupuncture approach revisited. Nephr Dial Transpl 2003; 324: 257-265Stockard H. Successful treatment of uremic pruritus: the acupuncture approach revisited. Nephr Dial Transpl 2003; 324: 257-265

The authors declare that there are no conflicts of interest present.