nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2012-16-3/1-54-71nefr-596Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESСТРЕСС ЭНДОПЛАЗМАТИЧЕСКОГО РЕТИКУЛУМА ГЛАЗАМИ НЕФРОЛОГА (СООБЩЕНИЕ I)NEPHROLOGIST’S IMPRESSION OF ENDOPLASMATIC RETICULUM STRESS (TEXT 1)ЗверевЯ. Ф.ZverevYa. F.

кафедра фармакологии

656038, г. Барнаул, пр. Ленина, д. 40. Тел.: (3852)26-08-35

zver@asmu.ruБрюхановВ. М.BruhanovV. M.

Кафедра фармакологии

Алтайского государственного медицинского университетаRussian Federation201210032012163/15471Copyright © Зверев Я.Ф., Брюханов В.М., 20122012Зверев Я.Ф., Брюханов В.М.Zverev Y.F., Bruhanov V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/596

В обзоре приводятся данные, касающиеся стресса эндоплазматического ретикулума (ЭПР-стресса). Приводятся сведения относительно биологической роли ЭПР-стресса, причин его возникновения, внутриклеточных событий, обеспечивающих развитие адаптивного и проапоптозного биохимических каскадов, лежащих в основе UPR, реакции на ЭПР-стресс, и определяющих судьбу клетки, подвергшейся воздействию этого стресса. Обсуждаются физиологические и патофизиологические аспекты ЭПР-стресса, его связь с гипоксией, воспалением, оксидативным стрессом. Рассматривается роль ЭПР-стресса в патогенезе ряда заболеваний.

Review provides data about endoplasmatic reticulum stress (ER-stress). Data about biological role of ER-stress, its causes, intracellular events which provide adaptive and proapoptotic biochemical cascades underlying UPR, ER-stress reaction and identifying fortune of cell which has been exposed to influence of this stress is given. Physiological and pathophysiological aspects of ER-stress are discussed, its connection with hypoxia, inflammation, oxidative stress. ER-stress role in pathogenesis of some diseases is observed.

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The authors declare that there are no conflicts of interest present.