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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1561-6274-2011-15-4-11-20</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-652</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕРЕДОВАЯ СТАТЬЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LEADING ARTICLE</subject></subj-group></article-categories><title-group><article-title>CОВРЕМЕННЫЙ ВЗГЛЯД НА ПАТОФИЗИОЛОГИЮ ВТОРИЧНОГО ГИПЕРПАРАТИРЕОЗА: РОЛЬ ФАКТОРА РОСТА ФИБРОБЛАСТОВ 23 И KLOTHO</article-title><trans-title-group xml:lang="en"><trans-title>CURRENT VIEW ON THE PATHOPHYSIOLOGY OF SECONDARY HYPERPARATHYROIDISM: ROLE OF FIBROBLAST GROWTH FACTOR 23 AND KLOTHO</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>ДОБРОНРАВОВ</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>DOBRONRAVOV</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Научноисследовательский институт нефрологии</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Санкт-Петербургскмй государственный медицинский университет им. акад. И.П. Павлова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>10</day><month>04</month><year>2011</year></pub-date><volume>15</volume><issue>4</issue><fpage>11</fpage><lpage>20</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; ДОБРОНРАВОВ В.А., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">ДОБРОНРАВОВ В.А.</copyright-holder><copyright-holder xml:lang="en">DOBRONRAVOV V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/652">https://journal.nephrolog.ru/jour/article/view/652</self-uri><abstract><p>Проанализированы современные представления о развитии и прогрессировании вторичного гиперпаратиреоза, основанные на новых данных о патофизиологии и молекулярных механизмах взаимодействия фосфат-регулирующих систем, в контексте значения фактора роста фибробластов 23 и Klotho</p></abstract><trans-abstract xml:lang="en"><p>Current concepts of secondary hyperparathyroidism development and progression based on new data about pathophysiology and molecular mechanisms of phosphate-regulating systems interactions in terms of fibroblast growth factor 23 and Klotho role</p></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая болезнь почек</kwd><kwd>вторичный гиперпаратиреоз</kwd><kwd>фактор роста фибробластов 23</kwd><kwd>klotho</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic kidney disease</kwd><kwd>secondary hyperparathyroidism</kwd><kwd>fibroblast growth factor 23</kwd><kwd>Klotho</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bricker N.S. 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