nefrНефрологияNephrology (Saint-Petersburg)1561-62742541-9439Pavlov First Saint-Petersburg State Medical University10.24884/1561-6274-2011-15-4-21-26nefr-655Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРОЛЬ СИСТЕМНОГО И ЛОКАЛЬНОГО ВОСПАЛЕНИЯ В РАЗВИТИИ ДИАБЕТИЧЕСКОЙ НЕФРОПАТИИTHE ROLE OF SYSTEMIC AND LOCAL INFLAMMATION IN DIABETIC NEPHROPATHYПЧЕЛИНИ. Ю.PCHELINI. Yu.

Кафедра факультетской терапии медицинского факультета

ШИШКИНА. Н.SHISHKINA. N.

Кафедра факультетской терапии медицинского факультета

ЛАПТЕВАО. А.LAPTEVAO. A.

Кафедра факультетской терапии медицинского факультета

Санкт-Петербургский государственный университетRussian Federation2011100420111542126Copyright © ПЧЕЛИН И.Ю., ШИШКИН А.Н., ЛАПТЕВА О.А., 20112011ПЧЕЛИН И.Ю., ШИШКИН А.Н., ЛАПТЕВА О.А.PCHELIN I.Y., SHISHKIN A.N., LAPTEVA O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.nephrolog.ru/jour/article/view/655

В статье представлен анализ современных данных о роли системного и локального воспаления в развитии диабетической нефропатии. Описаны различные аспекты влияния на почки провоспалительных цитокинов: фактора некроза опухолей-α, интерлейкина-1, интерлейкина-6, интерлейкина-18. Рассмотрены основные направления патогенетической терапии. Сделаны выводы о необходимости дальнейшего изучения воспалительных механизмов поражения почек при сахарном диабете, а также клинического и прогностического значения маркеров воспаления при диабетической нефропатии

The article contains analysis of contemporary data on the role of systemic and local inflammation in diabetic nephropathy. Renal effects of proinflammatory cytokines (tumor necrosis factor-α, interleukin-1, interleukin-6, interleukin-18) are described. The main directions of pathogenetic therapy are discussed. Further investigations are needed to elucidate inflammatory mechanisms of renal irritation at diabetes mellitus and prognostic relevance of inflammatory markers in patients with diabetic nephropathy

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The authors declare that there are no conflicts of interest present.