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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">nefr</journal-id><journal-title-group><journal-title xml:lang="ru">Нефрология</journal-title><trans-title-group xml:lang="en"><trans-title>Nephrology (Saint-Petersburg)</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1561-6274</issn><issn pub-type="epub">2541-9439</issn><publisher><publisher-name>Pavlov First Saint-Petersburg State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24884/1561-6274-2005-9-4-89-92</article-id><article-id custom-type="elpub" pub-id-type="custom">nefr-728</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЖУРНАЛ В ЖУРНАЛЕ. АКТУАЛЬНЫЕ ПРОБЛЕМЫ УРОЛОГИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>JOURNAL IN THE JOURNAL. ACTUAL PROBLEMS OF UROLOGY</subject></subj-group></article-categories><title-group><article-title>К КОМПЛЕКСНОМУ ЛЕЧЕНИЮ ГИПЕРАКТИВНОСТИ МОЧЕВОГО ПУЗЫРЯ У ЖЕНЩИН</article-title><trans-title-group xml:lang="en"><trans-title>ON COMPLEX TREATMENT OF HYPERACTIVITY OF THE URINARY BLADDER IN WOMEN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмин</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzmin</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра урологии</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Санкт-Петербургский государственный медицинский университет им.акад.И.П.Павлова</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2005</year></pub-date><pub-date pub-type="epub"><day>10</day><month>04</month><year>2005</year></pub-date><volume>9</volume><issue>4</issue><fpage>89</fpage><lpage>92</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кузьмин И.В., 2005</copyright-statement><copyright-year>2005</copyright-year><copyright-holder xml:lang="ru">Кузьмин И.В.</copyright-holder><copyright-holder xml:lang="en">Kuzmin I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://journal.nephrolog.ru/jour/article/view/728">https://journal.nephrolog.ru/jour/article/view/728</self-uri><abstract><p>ЦЕЛЬЮ ИССЛЕДОВАНИЯ явилось изучение эффективности комплексного лечения женщин с гиперактивностью мочевого пузыря. ПАЦИЕНТЫ И МЕТОДЫ. Проведено лечение 67 женщин с гиперактивностью мочевого пузыря. Всем пациентам назначали антихолинергический препарат детрузитол (толтеродин) по 2 мг дважды в день в течение 3 месяцев. Одновре менно с медикаментозной терапией проводили тренировку мочевого пузыря. Эффективность лечения оценивали на осно вании дневников мочеиспускания, результатам цистометрии до и после окончания лечения, а также субъективной оценке пациентов. РЕЗУЛЬТАТЫ. По окончании лечения 15 (22,4 %) женщин отметили полное исчезновение симптомов нарушения мочеиспускания, 42 (62,7 %) указали на улучшение, а 10 (14,9 %) – на отсутствие изменений в симптоматике заболевания. Выявлена также положительная динамика объективных параметров: снижение частоты мочеиспусканий, увеличение объе ма наполнения мочевого пузыря к моменту возникновения первого и максимального нестабильного сокращения детрузо ра, увеличение максимальной цистометрической емкости мочевого пузыря. Самым частым побочных эффектом явилась сухость во рту (20,9 % больных). ЗАКЛЮЧЕНИЕ. Комплексная терапия гиперактивности мочевого пузыря показала свою высокую эффективность, позволив добиться полного или частичного излечения у 85,1 % пациентов.</p></abstract><trans-abstract xml:lang="en"><p>THE AIM of the investigation was to study the efficiency of complex treatment of women with hyperactivity of the urinary bladder. PATIENTS AND METHODS. Treatment of 67 women with hyperactivity of the urinary bladder included administration of Detruzitol (Tolterodin) 2 mg daily during 3 months. Simultaneously with the medicamentous treatment the urinary bladder was trained. Efficiency of the treatment was assessed according to journals of urination, results of cystometry before and after treatment as by the subjective estimation of the patients. RESULTS. After treatment 15 (22.4%) women noted complete disappearance of symptoms of disturbances of urination, 42 (62.7%) showed an improvement, and 10 (14.9%) women had no changes in the symptoms of the disease. Positive dynamics in the objective parameters was found: less frequency of urination, increased volume of filling the bladder by the moment of the appearance of the first and maximal unstable reduction of Detruzitol, increase of the maximal cytometric capacity of the urinary bladder. The most frequent side effect was xerostomia (20.9% of the patients). CONCLUSION. Complex therapy of hyperactivity of the urinary bladder was shown to be highly effective and resulted in complete or partial healing in 85.1% of the patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мочевой пузырь</kwd><kwd>гирепактивность</kwd><kwd>женщины</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>urinary bladder</kwd><kwd>of the hyperactivity</kwd><kwd>women</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Abrams PH, Cardozo L, Fall M et al. The standardization of terminology of lower urinary tract function: report from the Standardization SubCommittee of the International Continence Society. Neurourol Urodyn 2002; 21:167178</mixed-citation><mixed-citation xml:lang="en">Abrams PH, Cardozo L, Fall M et al. The standardization of terminology of lower urinary tract function: report from the Standardization SubCommittee of the International Continence Society. Neurourol Urodyn 2002; 21:167178</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Mundy AR, Stephenson TP. The urge syndrome. In: Mundy AR,Stephenson TP, Wein AJ, eds. Urodynamics: Principles, Practice and Application. Churchill Livingstone, Edinburgh: 1984; 212228</mixed-citation><mixed-citation xml:lang="en">Mundy AR, Stephenson TP. The urge syndrome. In: Mundy AR,Stephenson TP, Wein AJ, eds. Urodynamics: Principles, Practice and Application. Churchill Livingstone, Edinburgh: 1984; 212228</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Milsom I, Abrams P, Cardozo L et al. How widespread are the symptoms of an overactive bladder and how are they managed? A populationbased prevalence study. BJU Int 2001; 87: 760766</mixed-citation><mixed-citation xml:lang="en">Milsom I, Abrams P, Cardozo L et al. How widespread are the symptoms of an overactive bladder and how are they managed? A populationbased prevalence study. BJU Int 2001; 87: 760766</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Stewart WF, Van Rooyen JB, Cundiff GW et al. Prevalence and burden of overactive bladder in the United States. World J Urol 2003; 20 (6): 327336</mixed-citation><mixed-citation xml:lang="en">Stewart WF, Van Rooyen JB, Cundiff GW et al. Prevalence and burden of overactive bladder in the United States. World J Urol 2003; 20 (6): 327336</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Abrams PH. Detrusor instability and bladder outlet obstruction. Neurourol Urodyn 1985; 4: P.317</mixed-citation><mixed-citation xml:lang="en">Abrams PH. Detrusor instability and bladder outlet obstruction. Neurourol Urodyn 1985; 4: P.317</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Hinman FJr. Critique of Urodynamics. In: Krane RJ, Siroky MB eds. Clinical Neuro-Urology. Little, Brown, Boston:1991; 161</mixed-citation><mixed-citation xml:lang="en">Hinman FJr. Critique of Urodynamics. In: Krane RJ, Siroky MB eds. Clinical Neuro-Urology. Little, Brown, Boston:1991; 161</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Jequier AM. Urinary symptoms in total hysterectomy. Br J Urol 1976; 48: 437</mixed-citation><mixed-citation xml:lang="en">Jequier AM. Urinary symptoms in total hysterectomy. Br J Urol 1976; 48: 437</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Morris AR, Mullan G, Roscioli T et al. A genetic linkage study of detrusor overactivity. Neurourol Urodyn 2004; 23 (5/6): 404</mixed-citation><mixed-citation xml:lang="en">Morris AR, Mullan G, Roscioli T et al. A genetic linkage study of detrusor overactivity. Neurourol Urodyn 2004; 23 (5/6): 404</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">АльШукри СХ, Кузьмин ИВ. Гиперактивность детрузора и ургентное недержание мочи. Пособие для врачей. СанктПетербург, 2001; 48</mixed-citation><mixed-citation xml:lang="en">АльШукри СХ, Кузьмин ИВ. Гиперактивность детрузора и ургентное недержание мочи. Пособие для врачей. СанктПетербург, 2001; 48</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Chapple CR. Muscarinic receptor antagonists in the treatment of overactive bladder. Urology 2000; 55 [Suppl.5A]: 3346</mixed-citation><mixed-citation xml:lang="en">Chapple CR. Muscarinic receptor antagonists in the treatment of overactive bladder. Urology 2000; 55 [Suppl.5A]: 3346</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wyman JF, Fantl JA. Bladder training in ambulatory care management of urinary incontinence. Urol Nurs 1991; 3: 1117</mixed-citation><mixed-citation xml:lang="en">Wyman JF, Fantl JA. Bladder training in ambulatory care management of urinary incontinence. Urol Nurs 1991; 3: 1117</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
