BONE TISSUE ADAPTATION PROCESSES AS AN ELEMENT OF DISORDERS MINERAL AND BONE METABOLISM PATHOGENESIS IN CHRONIC KIDNEY DISEASE
Abstract
THE AIM: to select adaptation mechanisms of bone structures reorganization which are involved in mineral and bone metabolism disorders in CKD following the own data and literature analysis. It is showed that one of the reasons for high sensitivity of bone tissue in particular and mineral metabolism in general to regulatory-metabolic shift in renal function disorder is the incorporation of osteocytes in lacunary-tubular system (LTS). This incorporation significantly limits cells nutrients delivery and metabolites removal. Therefore, during phylogeny in osteocytes formed a complex system of bone structures mechanical properties adaptive correction and LTS capacity which allows carrying out environmental parameters continuous optimization. As a result, osteocytes become one of the main mineral metabolism regulators of the body. Therefore, cells functioning adaptive shifts cause systemic effects associated also with mineral homeostasis parameters deviation outside the physiological limits. According to authors, it has become a clinical need to develop a non-invasive method for assessing the functional state of osteocytes. Proposed solutions to this problem using chronobiological method.
About the Authors
A. S. Avrunin
Russian Scientific research Institute of traumatology and orthopedics R.R.Vreden
Russian Federation
Russian Federation
N. V. Leontyeva
North-Western State Medical University I. I. Mechnikov
Russian Federation
Russian Federation
A. A. Doctorov
State scientific institution all-Russian Institute of medicinal and aromatic plants of the RAAS
Russian Federation
Russian Federation
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Avrunin A.S., Leontyeva N.V., Doctorov A.A. BONE TISSUE ADAPTATION PROCESSES AS AN ELEMENT OF DISORDERS MINERAL AND BONE METABOLISM PATHOGENESIS IN CHRONIC KIDNEY DISEASE. Nephrology (Saint-Petersburg). 2015;19(4):17-28. (In Russ.)
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