СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ ОБ ЭТИОЛОГИИ И ПАТОГЕНЕЗЕ ИДИОПАТИЧЕСКОЙ ГИПЕРКАЛЬЦИУРИИ
Аннотация
В обзоре обобщены данные об этиологии и патогенезе идиопатической гиперкальциурии. Рассматриваются основные виды гиперкальциурии. Обсуждаются различные причины и механизмы развития данного метаболического нарушения.
Об авторах
Н. М. Михеева
Алтайский государственный медицинский университет
Россия
Россия
Я. Ф. Зверев
Алтайский государственный медицинский университет
Россия
Россия
Г. И. Выходцева
Алтайский государственный медицинский университет
Россия
Россия
Список литературы
1. Liebman SE, Taylor JG, Bushinsky DA. Idiopathic hypercalciuria. Curr Rheumatol Rep 2006; 8 (1): 70-75
2. Spivacow FR, Negri AL, del Valle EE et al. Metabolic risk factors in children with kidney stone disease. Pediatr Nephrol 2008; 23: 1129-1133
3. Vezzoli G, Soldati L, Gambaro G. Hypercalciuria revisited: one or many conditions? Pediatr Nephrol 2008; 23: 503-506
4. Worcester EM, Coe FL. New insights into the pathogenesis of idiopathic hypercalciuria. Semin Nephrol 2008; 28 (2): 120-132
5. Bak M, Ural R, Agin H et al. The metabolic etiology of urolithiasis in Turkish children. Urol Nephrol 2009; 41: 453-460
6. Lau KK. Clinical manifestations of pediatric idiopathic hypercalciuria. Front Biosci(Elite Ed) 2009; 1: 52-59
7. Srivastava T, Schwaderer A. Diagnosis and management of hypercalciuria in children. Curr Opin Pediatr 2009; 21 (2): 214-219
8. Naseri M, Alamdaran SA. Metabolic factors associated with urinary calculi in children. Iran J Kidney Dis 2010; 4 (1): 32-38
9. Wróblewski T, Wystrychowski A. Hypercalciuria. Przegl Lek 2011; 68 (2): 107-113
10. Copelovitch L. Urolithiasis in children. Pediatr Clin North Am 2012; 59 (4): 881-896
11. Albright F, Henneman P, Benedict PH, Forbes AP. Idiopathic hypercalciuria: a preliminary report. Proc R Soc Med 1953; 46 (12): 1077-1081
12. Butani L, Kalia A. Idiopathic hypercalciuria in children - how valid are the existing diagnostic criteria? Pediatr Nephrol 2004; 19 (6): 577-582
13. Vezzoli G, Soldati L, Gambaro G. Update on primary hypercalciuria from a genetic perspective. J Urol 2008; 179: 1676-1682
14. Emamghorashi F, Davami MH, Rohi R. Hypercalciuria in Jahrom’s school-age children: what is normal calcium-creatinine ratio? Iran J Kidney Dis 2010; 4 (2): 112-115
15. Kaneko K, Tsuchiya K, Kawamura R et al. Low prevalence of hypercalciuria in Japanese children. Nephron 2002; 91: 439-443
16. Pak CY, Kaplan R, Bone H et al. A simple test to the diagnosis of absorptive, resorptive and renal hypercalciurias. N Engl J Med 1975; 292 (10): 497-500
17. Pak CY, Sakhaee K, Pearle MS. Detection of absorptive hypercalciuria type I without the oral calcium load test. J Urol 2011; 185(3): 915-919
18. Bataille P, Fardellone P, Ghazali A et al. Pathophysiology and treatment of idiopathic hypercalciuria. Curr Opin Rheumatol 1998; 10 (4): 373-388
19. Pak CX, Resnick MI. Medical therapy and new approaches to management of urolithiasis. Urol Clin North Am 2000; 27: 243253
20. Stapleton FB, Jones DP, Miller LA. Evaluation of bone metabolism in children with hypercalciuria. Semin Nephrol 1989; 9 (1): 75-78
21. Nicolaidou P, Themeli S, Karpathios T et al. Family pattern of idiopathic hypercalciuria and its subtypes. J Urol 1996; 155: 1042-1044
22. Maierhofer WJ, Lemann JJr, Gray RW, Cheung HS. Dietary calcium and serum 1,25-(OH)2-vitamin D concentrations as determinants of calcium balance in healthy men. Kidney Int 1984; 26 (5): 752-759
23. Scwaderer A, Srivastava T. Complications of hypercalci-uria. Front Biosci (Elite Ed) 2009; 1: 306-315
24. Curhan GC, Willett WC, Rimm EB, Stampfer MJ. Family history and risk of kidney stones. J Am Soc Nephrol 1997; 8 (10): 1568-1573
25. Polito C, La Manna A, Cioce F et al. Clinical presentation and natural course of idiopathic hypercalciuria in children. Pediatr Nephrol 2000; 15 (3-4): 211-214
26. Bianco SD, Peng JB, Takanaga H et al. Marked disturbance of calcium homeostasis in mice with targeted disruption of the Trpv6 calcium channel gene. J Bone Miner Res 2007; 22: 274-285
27. Jackman SV, Kibel AS, Ovuworie CA et al. Familial calcium stone disease: TaqI polymorphism and the vitamin D receptor. J Endocrinol 1999; 13: 313-316
28. Zerwekh JE, Reed BX, Heller HJ et al. Normal vitamin D concentration and responsiveness to 25-dihydroxyvitamin D3 in skin fibroblasts from patients with absorptive hypercalciuria. Miner Electrolyte Metab 1998; 24: 307-313
29. Lerolle N, Coulet F, Lantz B et al. No evidence for point mutations of the calcium-sensing receptor in familial idiopathic hypercalciuria. Nephrol Dial Transplant 2001; 16: 2317-2322
30. Petrucci M, Scott P, Ouimet D et al. Evaluation of the calcium-sensing receptor gene in idiopathic hypercalciuria and calcium nephrolithiasis. Kidney Int 2000; 58 (1): 38-42
31. Scheinman SJ, Cox JP, Lloyd SE et al. Isolated hypercalciuria with mutation in CLCN5: Relevance to idiopathic hypercalciuria. Kidney Int 2000; 57: 232-239
32. Scott P, Ouimet D, Proulx Y et al. The 1 alpha-hydroxylase locus is not linked to calcium stone formation or calciuric phenotypes in French-Canadian families. J Am Soc Nephrol 1998; 9 (3): 425-432
33. Lapointe J-Y, Tessier J, Paquette Y et al. NPT2a gene variation in calcium nephrolithiasis with renal phosphate leak. Kidney Int 2006; 69: 2261-2267
34. Reed BX, Gitomer WL, Heller HJ et al. Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab 2002; 87 (4): 1476-1485
35. Renkema KY, Lee K, Topala CN et al. TRPV5 gene polymorphisms in renal hypercalciuria. Nephrol Dial Transplant 2009; 24: 1919-1924
36. Moe OW, Bonny O. Genetic hypercalciuria. J Am Soc Nephrol 2005; 16 (3): 729-745
37. Frick KK, Bushinsky DA. Molecular mechanisms of primary hypercalciuria. J Am Soc Nephrol 2003; 14 (4): 1082-1095
38. Lemann JJr. Pathogenesis of idiopathic hypercalciuria and nephrolithiasis. In: Coe FL, Favus MJ, eds. Disorders of bone and mineral metabolism. Raven Press, New York, 1992; 685-706
39. Brannan PG, Morawaki S, Pak CYC, Fordtran JS. Selective jejuna hyperabsorption of calcium in absorptive hypercalciuria. Am J Med 1979; 68: 425-428
40. Lemann JJr. Idiopathic hypercalciuria. In: Coe FL, Favus MJ, eds. Disorders of bone and mineral metabolism. Lippincott, 2002;673-697
41. Coe FL, Parks JH, Evan AP, Worcester E. Pathogenesis and treatment of nephrolithiasis. In: Alpern R, Hebert S, eds. Seldin and Giebisch' The Kidney. Elsevier, Inc., 2007; 1945-1977
42. Hoenderop JGJ, Nilius B, Bindels RJM. Calcium absorption across epithelia. Physiol Rev 2005; 85: 373-422
43. Worcester EM, Gillen DL, Evan AP et al. Evidence that postprandial reduction of renal calcium reabsorption mediates hypercalciuria of patients with calcium nephrolithiasis. Am J Physiol Renal Physiol 2007; 292: 66-75
44. Tsuruoka S, Bushinsky DA, Schwartz GJ. Defective renal calcium reabsorption in genetic hypercalciuric rats. Kidney Int 1997; 51: 1540-1547
45. Sutton RAL, Walker VR. Responses to hydrochlorothiazide and acetazolamide in patients with calcium stones. N Engl J Med 1980; 13: 709-713
46. Prie D, Ravery V, Boccon-Gibod L, Friedlander G. Frequency of renal phosphate leak among patients with calcium nephrolithiasis. Kidney Int 2001; 60: 272-276
47. Tenenhouse HS, Gauthier C, Chau H, St-Arnaud R. 1 alpha-Hydroxylase gene ablation and Pi supplementation inhibit renal calcification in mice homozygous for the disrupted Npt2a gene. Am J Physiol Renal Physiol 2004; 286: F675-F681
48. Maierhofer WJ, Gray RW, Adams ND. Bone resorption stimulated by elevated serum 1,25-(OH)2-vitamin D concentrations in healthy men. Kidney Int 1983; 24 (4): 555-560
49. Bushinsky DA. Bench to bedside: Lessions from the genetic hypercalciuric stone forming rat. Am J Kidney Dis 2000; 36:61-64
50. Favus MJ, Karnauskas AJ, Park JH et al. Peripheral blood monocyte vitamin D receptor levels are elevated in patients with idiopathic hypercalciuria. J Clin Endocrinol Metab 2004; 89: 4937-4943
51. Sandgren M, DeLuca HF. Serum calcium and vitamin D regulate 1,25-dihydroxyvitamin D3 receptor concentration in rat kidney in vivo. Proc Natl Acad Sci U S A 1990; 87: 4312-4314
52. Yao J, Kathpalia P, Bushinsky DA, Favus MJ. Hyperresponsiveness of vitamin D receptor gene expression to 1,25-di-hydroxyvitamin D3. A new characteristic of genetic hypercalciuric stone-forming rats. J Clin Invest 1998; 101: 2223-2232
53. Alhava EM, Juuti M, Karjalainen P. Bone mineral density in patients with urolithiasis. Scand J Urol Nephrol 1976; 10: 154-156
54. Fuss M, Pepersack T, Van Geel J et al. Involvement of low calcium diet in the reduced mineral content in idiopathic renal stone formers. Calcif Tissue Int 1990; 46: 9-13
55. Casez JP, Hug C, Hess B et al. The myth of low bone mass in idiopathic calcium renal stone formers. Kidney Int 1993; 44: 264
56. Мальцев СВ, Михайлова ТВ, Кравцова ОА. Генетические и клинические аспекты нефролитиаза и нефрокальциноза у детей с гиперкальциурией. Практическая мед 2014; 9 (185): 118-125
57. Arrabal-Polo MA, del Carmen Cano-Garcia M, Canales BK, Arrabal-Martin M. Calcium nephrolithiasis and bone demineralization: pathophysiology, diagnosis, and medical management. Curr Opin Urol. 2014; 24(6): 633-638.
58. Zerwekh JE. Bone disease and idiopathic hypercalciuria. Semin Nephrol 2008; 28 (2): 133-142
59. Malluche HH, Tschoepe W, Ritz E et al. Abnormal bone histology in idiopathic hypercalciuria. J Clin Endocrinol Metab 1980; 50: 654-658
60. Weisinger JR. New insights into the pathogenesis of idiopathic hypercalciuria: the role of bone. Kidney Int 1996; 49: 1507-1518
61. Freundlich M, Alon US. Bisphosphonates in children with hypercalciuria and reduced bone mineral density. Pediatr Nephrol 2008; 23: 2215-2220
62. Heller HJ, Zerwekh JE, Gottschalk FA, Pak CY. Reduced bone formation and relatively increased bone resorption in absorptive hypercalciuria. Kidney Int 2007; 71: 808-815
63. Amanzadeh J, Gitomer W, Zerwekh JE et al. Effect of high protein diet on stone forming propensity and bone loss in rats. Kidney Int 2003; 64: 2142-2149
64. Nijenhuis T, Renkema KY, Hoenderop JGJ et al. Acid-base status determines the renal expression of Ca2+ and Mg2+ transport proteins. J Am Soc Nephrol 2006; 17: 617-626
65. Asplin JR, Bauer KA, Kinder J et al. Bone mineral density and urine calcium concentration among subjects with and without hypercalciuria. Kidney Int 2003; 63: 662-669
66. Lau KK, Butani L. Treatment strategies for pediatric idiopathic hypercalciuria. Front Biosci(Elite Ed) 2009; 1: 299-305
67. Borghi L, Schianchi T, Meschi T et al. Comparison of two diets for the prevention of recurrent stones in idiopathic hypercalciuria. N Engl J Med 2002; 346 (11): 77-84
68. Зверев ЯФ, Брюханов ВМ, Лампатов ВВ, Жариков АЮ. Современные представления о роли физико-химических факторов в патогенезе кальциевого нефролитиаза. Нефрология 2009; 13 (1): 39-50] 2009; 13 (1): 39-50
69. Caudarella R, Vescini F. Urinary citrate and renal stone disease: the preventive role of alkali citrate treatment. Arch Ital UrolAndrol 2009; 11 (3): 182-187
70. Dogliotti E, Vezzoli G, Nouvenne A et al. Nutrition in calcium nephrolithiasis. J Transl Med 2013, 11:109. Published online 2013, May 1. Doi: 10.1186/1479-5876-11-109
71. Penido MG, Lima EM, Souto MF et al. Hypocitruria: a risk factor for reduced bone mineral density in idiopathic hypercalciuria? Pediatr Nephrol 2006; 21: 74-78
72. Garcia-Nieto V, Ferrandez V, Monge M et al. Bone mineral density in pediatric patients with idiopathic hypercalciuria. Pediatr Nephrol 1997; 11 (5): 578-583
73. Dawson-Hughes B, Harris SS, Palermo NJ et al. Treatment with potassium bicarbonate lowers calcium excretion and bone resorption in older men and women. J Clin Endocrinol Metab 2009; 94: 96-102
74. Penido MGMG, Tavares MD, Linhares MC et al. Longitudinal study of bone mineral density in children with idiopathic hypercalciuria. Pediatr Nephrol 2012; 27: 123-130
75. Gambaro GF, Marchini MA, Nassuato A et al. The hyper-calciuric effect of PGE2 in nephrolithiasic patients is mediated by inhibition of Na-K-2Cl cotransport activity. In: Tiselius HG, Akademitryck AB, eds. Renal stones: Aspects of their formation, removal and prevention, Edsbruk, Sweden, 1995; 95-96
76. Hasanoglu A, Ercan ZS, Buyan N et al. Parathormone, 1,25-dihydroxyvitamin D and prostaglandin E2 correlation in children with idiopathic hypercalciuria. Prostaglandins Leukot Essent Fatty Acids 1997; 56 (3): 235-237
77. Krieger NS, Frick KK, Strutz KL et al. Regulation of COX-2 mediates acid-induced bone calcium efflux in vitro. J Bone Miner Res 2007; 22: 907-917
78. Zerwekh JE. Bone disease and hypercalciuria in children. Pediatr Nephrol 2010; 25: 395-401
79. Жариков АЮ, Зверев ЯФ, Брюханов ВМ, Лампатов ВВ. Механизм формирования кристаллов при оксалатном нефро-литиазе. Нефрология 2009; 13 (4): 37-50
80. Baggio D, Budakovic A, Nassuato A et al. Plasma phospholipid arachidonic acid content and calcium metabolism in idiopathic calcium nephrolithiasis. Kidney Int 2000; 58 (3): 1278-1284
81. Ortiz-Alvarado O, Miyaoka R, Kriedberg C et al. Omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid in the management of hypercalciuric stone formers. Urology 2012; 79 (2): 282-286
82. Зверев ЯФ, Брюханов ВМ, Талалаева ОС и др. О роли процессов свободно-радикального окисления в развитии экспериментального нефролитиаза. Нефрология 2008; 12 (1): 58-63
83. Мотина НВ, Зверев ЯФ, Лепилов АВ и др. Оксидатив-ное повреждение почек при экспериментальном оксалатном нефролитиазе. Нефрология 2010; 14 (1): 68-72
84. Pacifici R, Rothstein M, Rifers L et al. Increased monocyte interleukin-1 activity and decreased vertebral bone density in patients with fasting hypercalciuria. J Clin Endocrinol Metab 1990; 71 (1): 138-145
85. Classen N, Potgieter HC, Seppa M. Supplemented gamma-linolenic acid and eicosapentaenoic acid influence bone status in young male rats: Effects of free urinary collagen crosslinks, total urinary hydroxyproline, and bone calcium content. Bone 1995; 16: 385-392
86. Freundlich M, Alonzo E, Bellorini-Font E, Weisinger JR. Reduced bone mass in children with idiopathic hypercalciuria and in their asymptomatic mothers. Nephrol Dial Transplant 2002; 17 (8): 1396-1401
87. Santos Jr ACS, Lima EM, Penido MGMG et al. Plasma and urinary levels of cytokines in patients eith idiopathic hypercalciuria. Pediatr Nephrol 2012; 27: 941-948
88. Картамышева НН, Сергеева ТВ, Кучеренко АГ и др. Моноцитарный хемоаттрактивный протеин-1 (MCP-1) в патогенезе изменений тубулоинтерстициальной ткани у детей с хроническим гломерулонефритом. Нефрология и диализ 2005; 7 (4): 443-444
Рецензия
Для цитирования:
Михеева Н.М., Зверев Я.Ф., Выходцева Г.И. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ ОБ ЭТИОЛОГИИ И ПАТОГЕНЕЗЕ ИДИОПАТИЧЕСКОЙ ГИПЕРКАЛЬЦИУРИИ. Нефрология. 2015;19(4):29-40.
For citation:
Mikheeva N.M., Zverev Ya.F., Vykhodceva G.I. MODERN VIEWS ON IDIOPATHIC HYPERCALCIURIA AETIOLOGY AND PATHOGENESIS. Nephrology (Saint-Petersburg). 2015;19(4):29-40. (In Russ.)
Просмотров:
513
Послать статью по эл. почте 