VITAMIN D STATE AND CARDIOVASCULAR SYSTEM IN PATIENTS WITH CHRONIC KIDNEY DISEASE S5D STADE
Abstract
The AIM: to determine the relationship between vitamin D status and cardiovascular system state in patients with CKD S5d. PATIENTS AND METHODS. 103 patients receiving hemodialysis treatment (53 men and 50 women, mean age 54.8±15.2 years) were examined. Conventional clinical and laboratory parameters, serum parathyroid hormone (PTH) and carotid arteries intimamedia complex thickness were determined. 24-hour simultaneous ECG and blood pressure monitoring and echocardiography were performed. Vitamin D status indicators were determined by ELISA in 79 patients. RESULTS. The average serum calcidol concentration was 33.3±13,8 nmol/,l calcitriol - 11.5±6.9 pmol/l. Serum PTH level was decreased in 38 patients, normal - in 25 and increased in 40 patients. Vitamin D deficiency was associated with 3.9 times increased risk of coronary heart disease. Blood pressure circadian rhythm disturbances were associated with the most significant serum calcitriol concentration decrease: at diper - 15.9±9.2 pmol/l, at non-dipper - 9.3±5.1 pmol/l, p=0.034. CONCLUSION. Calcidol and calcitriol concentration overtime determining is necessary for personalized supplemental vitamin D prescription for patients with CKD S5d stade.
About the Authors
H. . Rafrafi
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
A. Sh. Rumyantsev
Pavlov First Saint Petersburg State Medical University; Saint Petersburg State University
Russian Federation
Russian Federation
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Review
For citations:
Rafrafi H., Rumyantsev A.Sh. VITAMIN D STATE AND CARDIOVASCULAR SYSTEM IN PATIENTS WITH CHRONIC KIDNEY DISEASE S5D STADE. Nephrology (Saint-Petersburg). 2015;19(4):51-54. (In Russ.)
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