THE EXPERIMENTAL BASIS FOR THE EFFICIENCY OF MAGNESIUM SALTS IN THE CORRECTION OF THE EXPERIMENTAL CALCIUM-PHOSPHATE NEPHROLITHIASIS

THE AIM. To study the influence of magnesium salt on the development of calcium-phosphate nephrolithiasis. MATERIALS AND METHODS. 42 male rats were on a calcium superfluous diet during 70 days (the content of elementary calcium in the diet exceeded in 1,8 times the normal daily need). After the level of crystaluria and calciuria of the animals with model-based pathology was reliably different from the control group, magnesium chloride, magnesium L – asparaginat, its combinations with vitamin B₆, magnesium sulphate and magne-B₆ in the dose of 50 mg of elementary magnesium on kg body weight was introduced per os through the stomach pump. RESULTS. After 70 days of the diet was noted the higher level of calcium and phosphate in the urine (to 49 % and 40 % than in the control group), twice increased the urine Ca/Mg ratio, appeared crystaluria. Inclusion volume fraction of calcificates in renal parenchyma was 14 %. In groups receiving magnesium salts and its combinations with vitamin B₆, was noted the lower level of calcium and phosphates in blood serum and urine, lower extend of crystaluria, lower volume and size of calcificates. The most effective was magnesium L – asparaginat, its combination with vitamin B₆ and magne-B₆. CONCLUSION. The further study of following magnesium salts as the remedy for the treatment of calcium-phosphate nephrolithiasis seems very promising.

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