MORPHOLOGICAL CHANGES IN KIDNEYS OF RATS WITH EXPERIMENTAL NEPHROLITHIASIS. A CASE OF PROLONGED USE OF CELL CULTURE MAACKIA AMURENSIS

Abstract

THE AIM. Determination of patterns of pathological changes in the kidneys of ethylene glycol model oxalate nephrolithiasis in prolonged use of the drug Maackia amurensis. MATERIAL AND METHODS. Experimental model oxalate nephrolithiasis was performed on 34 Wistar rats of both sexes weighing from 180 to 250 g. A morphological study of kidneys 34 rats was performed. Identification microlites calcium was determined by silver impregnation by Koss method. RESULTS. Established that prolonged use of the drug in terms of ethylene glycol oxalate nephrolithiasis model reduces the size and number of calcium deposits in the distal nephron. CONCLUSION. Application of cell culture extract Maackia amurensiscauses a decrease in the size and number of calcium deposits in a model of ethylene glycol oxalate nephrolithiasis and possibly potentiates the excretion of calcium microliths.