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MORPHOLOGICAL CHANGES IN KIDNEYS OF RATS WITH EXPERIMENTAL NEPHROLITHIASIS. A CASE OF PROLONGED USE OF CELL CULTURE MAACKIA AMURENSIS

https://doi.org/10.24884/1561-6274-2009-13-4-75-79

Abstract

THE AIM. Determination of patterns of pathological changes in the kidneys of ethylene glycol model oxalate nephrolithiasis in prolonged use of the drug Maackia amurensis. MATERIAL AND METHODS. Experimental model oxalate nephrolithiasis was performed on 34 Wistar rats of both sexes weighing from 180 to 250 g. A morphological study of kidneys 34 rats was performed. Identification microlites calcium was determined by silver impregnation by Koss method. RESULTS. Established that prolonged use of the drug in terms of ethylene glycol oxalate nephrolithiasis model reduces the size and number of calcium deposits in the distal nephron. CONCLUSION. Application of cell culture extract Maackia amurensiscauses a decrease in the size and number of calcium deposits in a model of ethylene glycol oxalate nephrolithiasis and possibly potentiates the excretion of calcium microliths.

About the Authors

N. V. Motina
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation


V. M. Bryukhanov
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation


O. V. Azarova
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation


A. Yu. Zharikov
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation


S. V. Talalaev
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation


V. P. Bulgakov
Дальневосточное отделение РАН, г. Владивосток
Russian Federation


S. A. Fedoreev
Дальневосточное отделение РАН, г. Владивосток
Russian Federation


N. P. Mishenko
Дальневосточное отделение РАН, г. Владивосток
Russian Federation


Yu. G. Motin
Алтайский государственный медицинский университет, г. Барнаул
Russian Federation


Review

For citations:


Motina N.V., Bryukhanov V.M., Azarova O.V., Zharikov A.Yu., Talalaev S.V., Bulgakov V.P., Fedoreev S.A., Mishenko N.P., Motin Yu.G. MORPHOLOGICAL CHANGES IN KIDNEYS OF RATS WITH EXPERIMENTAL NEPHROLITHIASIS. A CASE OF PROLONGED USE OF CELL CULTURE MAACKIA AMURENSIS. Nephrology (Saint-Petersburg). 2009;13(4):75-79. (In Russ.) https://doi.org/10.24884/1561-6274-2009-13-4-75-79

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)