ЛЕЧЕНИЕ ГЛОМЕРУЛОПАТИЙ ЦИКЛОСПОРИНОМ: ПРАВИЛЬНЫЙ ПОДХОД С НЕВЕРНЫМ ОБОСНОВАНИЕМ
Аннотация
В настоящее время мы являемся свидетелями процесса выхода практической медицины на новый виток своего развития. В мировой медицинской науке создана и набирает силу новая концепция «персонализированной медицины». Основу такой медицины XXI века составляют успехи генетики (фармакогенетики), молекулярной биологии, биохимии, физиологии (экспериментальные исследования). Ярким примером этому может служить почти 30-летняя история изучения вопроса об эффективности применения циклоспорина в лечении нефропатий. Сейчас можно считать доказанным, что циклоспорин действует не только на иммунокомпетентные клетки, но способен восстанавливать сложную структутрно-функциональную организацию подоцитов, существенно повреждающуюся при гломерулопатиях разного генеза. В настоящее время все большее число исследователей склоняются к мысли о том, что при ряде нефропатий (стероидрезистентная болезнь минимальных изменений, мебранозная нефропатия, фокально-сегментарный гломерулосклероз) комбинация циклоспорина с низкими дозами глюкокортикоидов может и должна рассматриваться в качестве терапии первой линии.
Об авторе
А. В. Смирнов
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия
Россия
кафедра пропедевтики внутренних болезней,
Научно-исследовательский институт нефрологии.
197022, Санкт-Петербург, ул. Л.Толстого, д. 17, СПбГМУ им. акад. И.П. Павлова, корп. 54, кафедра пропедевтики внутренних болезней. Тел.: (812) 234-01-65; Факс: (812) 234-65-30.
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Для цитирования:
Смирнов А.В. ЛЕЧЕНИЕ ГЛОМЕРУЛОПАТИЙ ЦИКЛОСПОРИНОМ: ПРАВИЛЬНЫЙ ПОДХОД С НЕВЕРНЫМ ОБОСНОВАНИЕМ. Нефрология. 2010;14(4):9-22. https://doi.org/10.24884/1561-6274-2010-14-4-9-22
For citation:
Smirnov A.V. GLOMERULOPATHY TREATMENT BY CYCLOSPORINE: THE RIGHT APPROACH WITH THE WRONG RATIONALE. Nephrology (Saint-Petersburg). 2010;14(4):9-22. (In Russ.) https://doi.org/10.24884/1561-6274-2010-14-4-9-22
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