GLOMERULOPATHY TREATMENT BY CYCLOSPORINE: THE RIGHT APPROACH WITH THE WRONG RATIONALE
https://doi.org/10.24884/1561-6274-2010-14-4-9-22
Abstract
Currently, we are witnessing the process practical medicine growing to a new stage in its development. In the world of medical science is created and gaining its strength a new concept of «personalized medicine». On the basis of such medicine lie the 21st century advances in genetics (pharmacogenetics), molecular biology, biochemistry, physiology (experimental studies). A striking example is the nearly 30-year history of research on the effectiveness of cyclosporine in the treatment of nephropathy. It can now be considered proven that cyclosporine acts not only on immunocompetent cells, but is able to restore the complex structural and functional organization of podocytes significantly damaged during glomerulopathies of different genesis. Currently, an increasing number of researchers are inclined to think that in a number of nephropathies (steroid resistant minimal changes disease, mebranous nephropathy, focal segmental glomerulosclerosis) a combination of cyclosporine with low-dose glucocorticoids can and should be treated as first-line therapy.
About the Author
A. V. Smirnov
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Smirnov A.V. GLOMERULOPATHY TREATMENT BY CYCLOSPORINE: THE RIGHT APPROACH WITH THE WRONG RATIONALE. Nephrology (Saint-Petersburg). 2010;14(4):9-22. (In Russ.) https://doi.org/10.24884/1561-6274-2010-14-4-9-22
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