STATE OF ENDOTHELIAL FUNCTION AND HEMOSTASIS SYSTEM IN PATIENTS ON HEMODIALYSIS
https://doi.org/10.24884/1561-6274-2010-14-4-48-52
Abstract
THE AIM of the study – to assess the state of endothelial function and indices of aggregation of platelet function, coagulation hemostasis and anticoagulant activity in patients on program hemodialysis treatment. PATIENTS AND METHODS. Examined 89 patients on hemodialysis. All patients measured the concentration of stable metabolites in blood serum (nitrites, nitrates, total metabolites of nitric oxide), indicators of lipid profile, homocysteine levels. The aggregation of platelets, coagulation hemostasis, anticoagulation activity, activation of blood coagulation tests were studied. RESULTS. Mean concentrations of homocysteine, von Willebrand factor in hemodialysis patients were higher than in the comparison group. The concentration of stable metabolites of nitric oxide in the studied group was significantly lower than in healthy individuals. Significant improvement of atherogenic lipoproteins in patients on hemodialysis was discovered. The changes in hemostasis indicate the presence of signs of activation of intravascular coagulation. According to the correlation analysis, multivariate regression analysis indicated the existence of a relationship between homocysteine concentration, indicators of atherogenic lipid profile, von Willebrand factor and indicators hemostaziogrammy. CONCLUSION. In patients receiving hemodialysis treatment there is activation of intravascular coagulation of blood does not reveal the routine coagulation studies. In patients on hemodialysis was revealed endothelial dysfunction. According to the correlation analysis, multivariate regression analysis there is an interrelation between indices of endothelial function and hemostasiogramma.
About the Authors
U. V. Kharlamova
Челябинская государственная медицинская академия
Russian Federation
Russian Federation
O. E. Il’icheva
Челябинская государственная медицинская академия
Russian Federation
Russian Federation
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Review
For citations:
Kharlamova U.V., Il’icheva O.E. STATE OF ENDOTHELIAL FUNCTION AND HEMOSTASIS SYSTEM IN PATIENTS ON HEMODIALYSIS. Nephrology (Saint-Petersburg). 2010;14(4):48-52. (In Russ.) https://doi.org/10.24884/1561-6274-2010-14-4-48-52
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