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UROMODULIN AND ION EXCRETION IN PATIENTS WITH GLOMERULOPATHY

Abstract

THE AIM: to assess the associations between serum (SUmo) or urinary (UUmo) uromodulin concentrations and the parameters of urinary excretion of various ions in patients with glomerulopathies. PATIENTS AND METHODS. Eighty four patients with different variants of glomerulopathies (M: F 42:42) were studied. Umo concentrations in serum (SUmo) and urine (UUmo) were measured by ELISA. Serum (SX) and urinary (UX) concentrations of creatinine, potassium, sodium, chloride, calcium, inorganic phosphorus, and protein levels in urine were stablished. Glomerular filtration rate (eGFR) was calculated using the CKD-EPI formula. For each ion calculated value of daily excretion (UX24), clearance (CX) and fractional excretion (EFX). RESULTS. SUmo significantly directly correlated (Spearman's rank correlation coefficient) with CK, UCa, UCa24, CCa, UMg24, CMg and inverse - with SK, EF.,, ER. , S_„ EF_., EFd and EF.. . UUmo was directly related to C, U_ „., C_ , U.. and inverse with S_.. UUmo and SUmo directly K’ Na’ Cl’ Cl’ P Mg3 K’ Ca24’ Ca’ Mg24 Cl3 correlated with each other and with the eGFR. CONCLUSION. These data suggest that uromodulina concentration in urine and especially in serum are associated with parameters of renal excretion of the some ions. It is possible that higher levels of serum uromodulin can contribute to renal retention of electrolytes. However, for the final solution of this question requires further study. Key words: uromodulin, glomerulopathy, ion excretion.

About the Authors

Mohamad Khasun
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation


Ivan G. Kayukov
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Научно-исследовательский институт нефрологии, лаборатория клинической физиологии почек
Russian Federation


Olga V. Galkina
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Научноисследовательский институт нефрологии
Russian Federation


Olga N. Beresneva
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Научно-исследовательский институт нефрологии
Russian Federation


Marina M. Parastaeva
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Научноисследовательский институт нефрологии
Russian Federation


Alexey V. Smirnov
Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова; Научноисследовательский институт нефрологии
Russian Federation


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Review

For citations:


Khasun M., Kayukov I.G., Galkina O.V., Beresneva O.N., Parastaeva M.M., Smirnov A.V. UROMODULIN AND ION EXCRETION IN PATIENTS WITH GLOMERULOPATHY. Nephrology (Saint-Petersburg). 2016;20(1):51-56. (In Russ.)

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)