PHYSICAL AND SEXUAL DEVELOPMENT OF ADOLESCENT GIRLS WITH RECURRENT URINARY TRACT INFECTIONS

Abstract

THE AIM: to study the peculiarities of physical and sexual development of adolescent girls with recurrent urinary tract infections.

PATIENTS AND METHODS. Examined 70 adolescent girls aged 16 – 18 years with exacerbation of chronic pyelonephritis (CP): 1 group  (n=43) – with rare relapse history (relapses pyelonephritis from 1 to 3 times during the period of the disease, rCP) and group 2 (n=27)  with frequent relapses (more than 3 times a year, fCP). The control  group (n=30) consisted of practically healthy adolescent girls of the  same age. Anthropometry, evaluation of sexual development,  specialized gynecological examination, determination of serum  hormones, ultrasound examination of the reproductive organs were  carried out. Statistical processing of research results was performed  using the software packages Statistica 6.0 ("StatSoft Inc", USA) and  statistical analysis Microsoft Office Excel 2003" ("Microsoft Corporation", USA).

RESULTS. It was revealed that in patients with rCP, compared with  girls of the 1st and control groups, there was a lower growth, a  decrease in the basic pelvic dimensions, against the background of a  tendency to increase weight, there were some variants of sexual  disorders, more often than in other groups there were early pubarche and later menarche. Established significant increase in the level of LH, testosterone and DHEA-S in the background of  hypoprogesteronemia. The rate of hyperpolymenorrhea, uterine  bleeding and primary oligomenorrhea was significantly higher, were often found emerging polycystic ovary syndrome and chronic vulvovaginitis.

CONCLUSION. Patients with frequent recurrence of urinary tract  infections have a variety of constitutional features, a tendency to  metabolic syndrome development, expressed hormonal status  violations. The detected increase in testosterone levels contributes to the emerging polycystic ovaries syndrome development.