Apelin/APJ signal system and glomerular filtration rate in various variants of bronchial asthma
https://doi.org/10.36485/1561-6274-2020-24-4-55-60
Abstract
INTRODUCTION. We have previously postulated the similarity of molecular pathogenetic mechanisms in bronchial asthma (BA) and chronic kidney disease (CKD). Understanding these mechanisms in such a comorbidity pathology is of interest to the clinicians. In recent years, the attention of BA pathogenesis researchers has attracted low-investigated adipokine – apelin. On the other hand, apelin is considered as a renoprotective adipokine that can prevent the progression of CKD.
THE AIM of the study is to identify the relationship between apelin/APJ signaling system and glomerular filtration rate in different BA variants.
PATIENTS AND METHODS. The 12 of practically healthy persons and 36 bronchial asthma patients were examined. Levels of apelin-12, apelin-36, and APJ receptor of apelines on peripheral blood lymphocytes were determined, as well as levels of TNF-α, IL-6 IL-4 by immunoenzyme method according to standard protocol. Glomerular filtration rate (eGFR) by CKD-EPI was calculated.
RESULTS. With the help of factor analysis, it was revealed that the glomerular filtration rate in bronchial asthma is associated with the level of apelin-36. A high level of glomerular filtration rate corresponds to a high level of apelin-36. In bronchial asthma, the negative association of pro-inflammatory adipokines TNF-α and IL-6 with the glomerular filtration rate was revealed. On the other hand, the IL-4 was found to be directly related to the glomerular filtration rate according to the factorial analysis.
CONCLUSION. The obtained data suggest a possible renoprotective effect of apelin-36 in bronchial asthma.
About the Authors
V. N. Mineev
Research Institute of rheumatology and allergology, Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Prof. Valerii N. Mineev, MD, PhD, DMedSci, professor of Department of Hospital Therapy
197022, St-Petersburg, L. Tolstoy st., 17, build. 54
Phone 8(921)3596295
A. A. Kuzmina
Research Institute of rheumatology and allergology, Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Anna A. Kuzmina MD, PhD, assistant professor of Department of Hospital Therapy
197022, St-Petersburg, L. Tolstoy st., 17, build. 54
Phone 8(953)165-98-71
T. M. Lalaeva
Research Institute of rheumatology and allergology, Pavlov First Saint-Petersburg State Medical University
Russian Federation
Russian Federation
Tatyana M. Lalaeva doctor of medical sciences MD, PhD, DMedSci, associate professor of Department of Hospital Therapy
197022, St-Petersburg, L. Tolstoy st., 17, build. 54
Phone 8(911)912-80-43
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Review
For citations:
Mineev V.N., Kuzmina A.A., Lalaeva T.M. Apelin/APJ signal system and glomerular filtration rate in various variants of bronchial asthma. Nephrology (Saint-Petersburg). 2020;24(4):55-60. (In Russ.) https://doi.org/10.36485/1561-6274-2020-24-4-55-60
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