Influence of long-term injection of 6-propyl-2-thiouracilum on dynamics of indicators of renal function in rats
Abstract
THE AIM: to study of renal function in rats, depending on the duration of administration of 6-propyl-2-thiouracil. MATHERIAL AND METHODS. Rats were administered 6-propyl-2-thiouracil orally every day for 7 or 25 days. Activity of kidneys was observed under condition of 5% water load, considering 5 ml of water to 100 g of body weight. RESULTS. It was established that renal function in rats depends on the duration of drug administration. In the early stages of the experiment, there is a moderate increase in the values of glomerular filtration rate, reduction of renal excretion of osmotically active substances, fluids and proteins, decrease in extracellular fluid osmolality. Long-term administration of the drug is accompanied by normalization of glomerular filtration rate, amd there is no significant increase in proteinuria, and a significant reduction in the excretion of osmotically active substances and the level of plasma osmolality. There were not found signs of toxic effects of propylthiouracil on the kidney activity in rats. CONCLUSION. The recorded changes in renal function caused by hypothyroid status and not related to the toxic effect of propylthiouracil on the activity of rat kidneys.
About the Authors
Sergey I. Dolomatov
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Nikolay J. Novikov
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Petr M. Klymenko
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Igor N. Kasich
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
Ilya V. Myshko
V.I. Vernadsky Crimean Federal University
Russian Federation
Russian Federation
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Review
For citations:
Dolomatov S.I., Novikov N.J., Klymenko P.M., Kasich I.N., Myshko I.V. Influence of long-term injection of 6-propyl-2-thiouracilum on dynamics of indicators of renal function in rats. Nephrology (Saint-Petersburg). 2016;20(4):98-102. (In Russ.)
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