АНТИ-C1q АУТОАНТИТЕЛА: НОВЫЕ ТЕСТЫ И КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ
Аннотация
Хотя анти-dq аутоантитела были описаны более четырех десятилетий назад, постоянный поток статей, описывающих клинические ассоциации или функциональные последствия подтверждает, что анти-dq антитела по-прежнему актуальны. Безусловное большинство исследований сосредоточились на анти-C1q антителах при системной красной волчанке (СКВ). При СКВ анти-C1q антитела ассоциированы с наличием волчаночного нефрита и при их отсутствии развитие обострения нефрита маловероятно. Анти-C1q антитела встречаются не только при ряде аутоиммунных состояний, но также и у здоровых лиц. Несмотря на значительный прогресс, который был достигнут в понимании того, как анти-C1q антитела могут участвовать в повреждении тканей, до сих пор еще многое предстоит узнать о процессах, приводящих к нарушению толерантности к этому белку. Значительно усовершенствованы тесты, используемые для выявления анти-C1q антител. Надо надеяться, что эти новые стандартизированные тесты будут в ближайшее время использоваться при проведении крупных исследований клинических ассоциаций с независимой оценкой результатов. Подобные крупномасштабные исследования выявят истинное значение тестов на анти-C1q аутоантитела при ряде клинических состояний.
Об авторах
М. . Малер
INOVA Diagnostics, Inc
Россия
Россия
Р. А. Ван Шаренбург
Лейденский университет
Россия
Россия
Л. А. Трау
Лейденский университет
Россия
Россия
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Для цитирования:
Малер М..., Ван Шаренбург Р.А., Трау Л.А. АНТИ-C1q АУТОАНТИТЕЛА: НОВЫЕ ТЕСТЫ И КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ. Нефрология. 2014;18(1):8-13.
For citation:
Mahler M..., Van Schaarenburg R.A., Trouw L.A. Anti-C1q autoantibodies, novel tests, and clinical consequences. Nephrology (Saint-Petersburg). 2014;18(1):8-13. (In Russ.)
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