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Systemic inflammation factors influence on the risk of detecting signs of cardiovascular calcification in a patient with stage 5D chronic kidney disease

https://doi.org/10.36485/1561-6274-2023-27-1-86-91

Abstract

   BACKGROUND. Chronic kidney disease (CKD) is a common pathology influencing mortality risk in the world population. Calcification of aorta and heart structures (valves, coronary arteries) is a risk factor for cardiovascular complications. The influence of cytokines, integrin proinflammatory indices, acute phase proteins and other inflammatory factors on the risk of extravasal calcification is promising.

   THE AIM: to study the effect of cytokines, integrative proinflammatory indices, acute phase proteins and other inflammatory factors on the risk of extra-osseous calcification.

   PATIENTS AND METHODS. A one-stage, cohort study of 85 patients with CKD 5D treated with programmed hemodialysis was conducted. General clinical examination was carried out according to the protocol. Blood levels of C-reactive protein (CRP) were determined by immunoturbodimetry. A Glasgow Prognostic Score (GPS) risk index for systemic inflammation was calculated using CRP and plasma albumin concentrations. Interleukin-6 (IL-6), interleukin-3 (IL-3) were assessed by enzyme immunoassay. Blood leukocyte shift index (BLI) was calculated. Echocardioscopy was performed using Doppler mode. The presence of cardiac valve calcification (CAC) was registered, its severity was assessed. To estimate the abdominal aortic calcification, the abdominal radiography was carried out in the left lateral projection. The severity of manifestations of aortic calcification was assessed using the L.I. Kauppilla Calcification Scale. Statistical analysis was performed using STATISTICA 12.6. toolkit (StatSoft, USA).

   RESULTS. Systemic inflammatory factors negatively affected the severity of cardiovascular calcification. An increased GPS value was found to correlate with the severity of CAC and CSA. In the case of calcification severity analysis considering IL-3 and IL-6 values, it was also shown that high levels of these pro-inflammatory cytokines are associated with severe manifestations of anterior aortic wall calcification and aortic calcification at the L3 level. Inclusion of ISLC in the analysis had no effect on the severity of calcification of the aortic wall and no effect on the intensity of cardiac valve calcification in general, the aortic valve and the mitral valve in particular.

About the Authors

A. M. Mambetova
Kabardino-Balkar State University named after Kh. M. Berbekov
Russian Federation

Aneta M. Mambetova, Professor, MD, PhD, DMedSci, Professor of the Department

Department of general medical education and medical rehabilitation

360000

Chernyshevsky str., 173

Kabardino-Balkar Republic

Nalchik

Phone: +78662930080

Mobile: +79054391190



M. H. Hutueva
Republican clinical hospital named after Sh. Sh. Ependiev
Russian Federation

Madina H. Hutueva, MD

anesthesiology and intensive care unit

364047

Khvoynaya street, 5

Chechen Republic

Grozniy



I. K. Thabisimova
Kabardino-Balkar State University named after Kh. M. Berbekov
Russian Federation

Irina K. Thabisimova, Associate Professor, MD, PhD

Department of general medical education and medical rehabilitation

360000

Chernyshevsky str., 173

Kabardino-Balkar Republic

Nalchik



References

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Review

For citations:


Mambetova A.M., Hutueva M.H., Thabisimova I.K. Systemic inflammation factors influence on the risk of detecting signs of cardiovascular calcification in a patient with stage 5D chronic kidney disease. Nephrology (Saint-Petersburg). 2023;27(1):86-91. (In Russ.) https://doi.org/10.36485/1561-6274-2023-27-1-86-91

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)