The problem of focal-segmental glomerulosclerosis in primary glomerulonephritis
https://doi.org/10.36485/1561-6274-2023-27-1-108-114
Abstract
The concept of focal segmental glomerulosclerosis in clinical practice is used to describe both a separate disease and morphological characteristics of secondary kidney damage. Most often, focal segmental glomerulosclerosis occurs as a result of the course of primary glomerulonephritis and is the cause of the development of nephrotic syndrome. A feature of the course of nephrotic syndrome in focal segmental glomerulosclerosis is a longer response to steroid therapy, or the formation of dependence/resistance to glucocorticosteroids. Despite the development of scientific progress, the problem of focal segmental glomerulosclerosis in primary glomerulonephritis is still relevant. Understanding the mechanisms of podocyte damage and disease progression is important not only for basic research, but also for everyday clinical practice.
Keywords
сhildren,
glomerulonephritis,
nephrotic syndrome,
focal segmental glomerulosclerosis,
podocytes,
immunosuppressive therapy
Supporting agencies: The work was carried out within the framework financing of the State task “Clinical and molecular genetic criteria for predicting the effectiveness of steroid and immunosuppressive therapy for primary nephrotic syndrome in children”, № 200080056
About the Authors
S. L. Morozov
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Sergey L. Morozov
Research Clinical Institute of Pediatrics named after acad. Yu. E. Veltishcheva
Faculty of Pediatrics
Department of Hospital Pediatrics No. 2
Moscow
V. V. Dlin
Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Vladimir V. Dlin
Research Clinical Institute of Pediatrics named after acad. Yu. E. Veltishcheva
Moscow
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Review
For citations:
Morozov S.L., Dlin V.V. The problem of focal-segmental glomerulosclerosis in primary glomerulonephritis. Nephrology (Saint-Petersburg). 2023;27(1):108-114. (In Russ.) https://doi.org/10.36485/1561-6274-2023-27-1-108-114
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