ANALYSIS OF KIDNEY FUNCTIONAL STATUS AT URINARY INCONTINENCE IN WOMEN
https://doi.org/10.24884/1561-6274-2017-21-1-73-79
Abstract
AIM: to analyze functional state of kidneys in women with urinary incontinence. PATIENTS AND METHODS: 277 women with complaints on urinary incontinence and 14 healthy women aged 18 to 55 years were examined. 143 women was diagnosed stress urinary incontinence, 43 – urge urinary incontinence and 91 – mixed urine incontinence. Nycturia was revealed in 24 women and polyuria – in 60 women with urine incontinence. The increased diuresis, water reabsorption in collecting ducts, ion excretion including Na and Mg ion were higher during the night in patients with nycturia and during the day in patients with polyuria in comparison with healthy patients. Use of desmopressin (minirin) in a dose of 100 mcg reduced diuresis and ion excretion to normal levels. It is suggested that the main role in the pathogenesis of kidney functions in patients with polyuria and nycturia is played by a decrease of ion reabsorption in the thick ascending Henle loop, which results in higher load of collecting ducts by liquid, increase of diuresis and electrolytes excretion. Use of desmopressin in these patients is pathogenetically proved because it removes main tubular defect.
Keywords
urine incontinence,
polyuria,
nycturia,
desm,
opressin,
kidney,
water reabsorption,
Na excretion,
Mg excretion
About the Authors
N. A. Osipova
Saint-Petersburg State University
Russian Federation
Russian Federation
Natalya A. Osipova, MD, PhD
Department of obstetrics, gynecology and Reproductology
199106, St. Petersburg ,V.I., 21st line, 8a
D. A. Niauri
Saint-Petersburg State University
Russian Federation
Russian Federation
Dariko A. Niauri MD, PhD, DMedSci.
Department of obstetrics, gynecology and Reproductology, chief.
199106, St. Petersburg ,V.I., 21st line, 8a
A. M. Gzgzyan
Saint-Petersburg State University
Russian Federation
Russian Federation
Alexander M. Gzgzyan MD, PhD, DMedSci
Department of obstetrics, gynecology and Reproductology
199106, St. Petersburg ,V.I., 21st line, 8a
W. L. Emanuel
First Pavlov Saint Petersburg State Medical University
Russian Federation
Russian Federation
Vladimir L. Emanuel MD, PhD, DMedSci
Department of clinical laboratory diagnostics with a course of molecular medicine, chief.
199106, St. Petersburg ,V.I., 21st line, 8a.
References
1. Миронов ВН. Клиническая оценка урологических симптомов при пролапсе тазовых органов 4 стадии у женщин. Нефрология 2014;18(4):62-67 [Mironov VN. Clinicheskaia ocenka urologicheskikh simptomov pri prolapse tazovy`kh organov 4 stadii u zhenshchin. Nefrologiia 2014;18(4):62-67]
2. Аполихина ИА, Ромих ВВ, Андикян ВМ. Современные принципы консервативного лечения недержания мочи у женщин. Урология 2005; 5: 72-75 [Apolihina IA, Romih VV, Andikjan VM. Sovremennye principy konservativnogo lechenija nederzhanija mochi u zhenshhin. Urologija 2005; 5: 72-75]
3. Пушкарь ДЮ, Щавелева ОБ. Диагностика и результаты лечения смешанных форм недержания мочи у женщин. Урология 2005; 3: 22-25 [Pushkar’ DJu, Shhaveleva OB. Diagnostika i rezul’taty lechenija smeshannyh form nederzhanija mochi u zhenshhin. Urologija 2005; 3: 22-25]
4. Hampel C, Wienhold D, Benken N et al. Prevalence and natural history of female incontinence. Eur Urol 1997;32 (Suppl. 23.12): 23–32
5. Наточин ЮВ, Кузнецова АА. Ночной энурез как проявление аутакоидоза. Тер арх 1997;(12): 67-72 [Natochin JuV, Kuznecova AA. Nochnoj jenurez kak projavlenie autakoidoza. Ter arh 1997;(12): 67-72]
6. Гуткина ОГ, Наточин ЮВ. Исследование роли аутакоидов в регуляции циркадного ритма мочеобразования у человека. Росс физиол журн им. И.М. Сеченова 2005; 91 (11): 1338-1346 [Gutkina OG, Natochin JuV. Issledovanie roli autakoidov v reguljacii cirkadnogo ritma mocheobrazovanija u cheloveka. Rossijskij fiziologicheskij zhurnal im. I.M. Sechenova 2005; 91 (11): 1338-1346]
7. Осипова НА, Ниаури ДА, Зиятдинова ГМ. Суточный ритм мочеобразования и мочеотделения при недержании мочи у женщин. Гинекология 2015; 17 (2):74-76 [Osipova NA, Niauri DA, Zijatdinova GM. Sutochnyj ritm mocheobrazovanija i mocheotdelenija pri nederzhanii mochi u zhenshhin. Ginekologija 2015; 17 (2):74-76]
8. Наточин ЮВ. Физиология почки: формулы и расчеты. Наука, Л., 1974. [Natochin JuV. Fiziologija pochki: formuly i raschety. L.: Nauka, 1974]
9. Clinical guidelines for nocturia. Committee for Establishment of the Clinical Guidelines for Nocturia of the Neurogenic Bladder Society. Int J Urol 2010;17(5):397-409. doi: 10.1111/j.1442-2042.2010.02527.x.
10. van Kerrebroeck P, Abrams P, Chaikin D et al. The standardization of terminology in nocturia: report from the Standardization Subcommittee of the International Continence Society. Neurourol Urodyn 2000; 211: 79–83. DOI: 10.1046/j.1464-410X.90.s3.3.x
11. Кузнецова АА, Наточин ЮВ, Папаян АВ. Физиологический анализ ионорегулирующей функции почки детей при энурезе. Физиол журн им. И.М. Сеченова 1996; 82(12): 78-86 [Kuznecova AA, Natochin JuV, Papajan AV. Fiziologicheskij analiz ionoregulirujushhej funkcii pochki detej pri jenureze. Fiziologicheskij zhurnal im. I.M. Sechenova 1996; 82(12): 78-86]
12. Greger R. Renal handling of the individual solutes of glomerular filtrate. Comprehensive human physiology. Eds. Greger R., Windhorst U. Berlin, Heidelberg: Springer. 1996; 2:1517-1544
13. Rouffignac С. Multihormonal regulation of nephron epithelia achieved through combinational mode. Am J Physiol 1995; 269 (4): R739 -R748
Review
For citations:
Osipova N.A., Niauri D.A., Gzgzyan A.M., Emanuel W.L. ANALYSIS OF KIDNEY FUNCTIONAL STATUS AT URINARY INCONTINENCE IN WOMEN. Nephrology (Saint-Petersburg). 2017;21(1):73-79. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-1-73-79
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