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Nephrology (Saint-Petersburg)

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Hyperuricemia and the nephrocerebral continuum

https://doi.org/10.36485/1561-6274-2025-29-2-9-16

EDN: FQWGFC

Abstract

Uric acid plays an important role in the development of kidney disease and cerebrovascular diseases. The kidneys play a crucial role in regulating serum uric acid levels, accounting for 60-70 % of uric acid excretion. Normally, the kidneys reabsorb about 90 % of the uric acid filtered by the glomeruli in the proximal tubules. Uric acid is a product of the breakdown of purines and can perform many physiological functions, including antioxidant and neuroprotective, maintaining blood pressure when taken with a low salt content and modulating immunity. However, excessive production of uric acid and/or an imbalance of renal secretion and reabsorption of uric acid and/or insufficient excretion of extrarenal uric acid, for example, in the intestine, will contribute to hyperuricemia, which is a common metabolic disease. Hyperuricemia and gout are associated with numerous cardiovascular and renal disorders, such as hypertension, myocardial infarction, stroke, obesity, hyperlipidemia, type 2 diabetes mellitus and chronic kidney disease. The article discusses the nephrocerebral continuum in hyperuricemia.

For citations:


Yusupov F.A., Ydyrysov I.T., Yuldashev A.A. Hyperuricemia and the nephrocerebral continuum. Nephrology (Saint-Petersburg). 2025;29(2):9-16. (In Russ.) https://doi.org/10.36485/1561-6274-2025-29-2-9-16. EDN: FQWGFC

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)