Relationship of circulation cytokines and blood lipid spectrum with renal functional parameters in persons with various cardiovascular risk

THE AIM of the study was to study the relationship between circulating cytokines and blood lipid profiles and their role in the development of kidney dysfunction in individuals with different categories of cardiovascular risk. We examined 249 people with different categories of cardiovascular risk (CVR) according to the SCORE scale: low-moderate cardiovascular risk (n = 92); high CV risk (n = 100); very high (n = 57). Along with general clinical data, the following biochemical parameters were assessed: concentrations of tumor necrosis factor-alpha (TNF-α), interleukin (IL)-6 and IL-10, the ratio of inflammatory and anti-inflammatory cytokines, as well as the levels of total cholesterol (CHC), lipoprotein cholesterol low density (LDL-C), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), atherogenic index (AI), serum cystatin C and creatinine with calculation of glomerular filtration rate (GFR).

PATIENTS AND METHODS. Show that in individuals with very high cardiovascular risk, the level of systolic blood pressure, the median concentrations of IL-6 and IL-10 were significantly higher. Estimated GFR based on serum cystatin C levels in all studied subgroups was significantly lower than GFR calculated based on blood creatinine. RESULTS. A close correlation was demonstrated between the concentration of TNF-α with the level of LDL-C (r = 0.138, p<0.05), HDL-C (r = – 0.193, p<0.05), AI (r = 0.140, p<0.05) on the one hand and between IL-6 with LDL-C (r = 0.253, p<0.05), HDL-C (r = -0.174, p<0.05) on the other. There was a negative relationship between the level of TNF-α and GFR calculated from both creatinine (r= -0.270, p<0.05) and cystatin C (r= -0.308, p<0.05).

CONCLUSION. The most pronounced violations of cytokine metabolism with an increase in TNF-α, IL-6 and a decrease in IL-10 are observed as the CVR increases, especially in people with very high CVR. In individuals with different categories of CV risk, elevated levels of TNF-α and IL-6 are actively involved in lipid metabolism disorders, contributing to the progression of atherosclerosis and the development of kidney dysfunction.

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