Urolithiasis and the major urinary protein

N. A. Verlov; K. R. Dyussupova; V. L. Emanuel

doi:10.36485/1561-6274-2025-29-4-37-43

Urolithiasis and the major urinary protein

N. A. Verlov, K. R. Dyussupova, V. L. Emanuel

https://doi.org/10.36485/1561-6274-2025-29-4-37-43

EDN: XQQPWY

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Abstract

The pathogenetic approach to metaphylaxis of urolithiasis is a widespread, socially significant healthcare issue due to the increasing incidence and, particularly, its recurrent nature, despite advances in pharmacotherapy and the application of lithotripsy. Pathological crystal genesis is viewed as a consequence of exceeding the solubility threshold of various urinary mineral components on one hand, and as a result of post-translational defects in the main proteome of urine formation – uromodulin (UMOD), which demonstrates a sanogenetic system in healthy individuals for maintaining biophysical homeostasis stability: the colloidal properties of urine. However, in addition to this, UMOD, by binding mannose-dependent pili of infectious agents, blocks bacterial contact with urothelial cells, given that urinary tract infection is a known factor in urolithiasis. By modeling the urine of healthy individuals through co-incubation with E. coli bacteria, a decrease in the concentration of polymerized uromodulin in urine has been demonstrated as a factor increasing the risk of calcium oxalate crystal formation.

Keywords

urolithiasis, biocrystallomics, proteome, uromodulin, biophysical homeostasis, colloidal properties of urine, E. coli, calcium oxalate

About the Authors

N. A. Verlov

Petersburg Nuclear Physics Institute named by B.P.Konstantinov of National Research Centre «Kurchatov Institute»
Russian Federation

Nikolay A. Verlov, Ph.D.

188300, Russia, Leningradskaya oblast, Gatchina 1, mkr. Orlova roshcha

Phone: +7 (813) 714-60-93

K. R. Dyussupova

First Pavlov State Medical University of St. Petersburg
Russian Federation

Karina R. Dyussupova

197022, Russia, Saint-Petersburg, 197022, Russia, St-Petersburg, L. Tolstoy st., 6-8, build 11

V. L. Emanuel

First Pavlov State Medical University of St. Petersburg
Russian Federation

Vladimir L. Emanuel

197022, Russia, St-Petersburg, L. Tolstoy st., 6-8, build 11

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Review

For citations:

Verlov N.A., Dyussupova K.R., Emanuel V.L. Urolithiasis and the major urinary protein. Nephrology (Saint-Petersburg). 2025;29(4):37-43. (In Russ.) https://doi.org/10.36485/1561-6274-2025-29-4-37-43. EDN: XQQPWY

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ISSN 2541-9439 (Online)

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Nephrology (Saint-Petersburg)

Urolithiasis and the major urinary protein

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Abstract

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About the Authors

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