FEATURES OF THE COURSE OF IDIOPATHIC HYPERCALCIURIA IN CHILDREN. ANALYSIS OF CLINICAL AND LABORATORY MANIFESTATIONS
https://doi.org/10.24884/1561-6274-2017-21-4-68-72
Abstract
THE AIM: to study clinical and laboratory manifestations of hypercalciuria in children of Barnaul, living in the zone of sharply continental climate of the South of Western Siberia. PATIENTS AND METHODS. The study included 239 children aged from 1 month to 16 years (mean age of 6.6±2,72 years) with idiopathic hypercalciuria (IH), diagnosed according to the level of calcium/creatininemia coefficient (CCC), more than 0.6 mmol/mmol and normal plasma calcium and parathyroid hormone. Conducted physical examination and biochemical blood and urine determination of calcium, phosphorus, creatinine, urea and uric acid, ultrasound of the kidneys and bladder, radiopaque research methods indicated. RESULTS. Family history of urolithiasis have been reported in 56.1% children with hypercalciuria. Analysis of comorbidity showed a combination of IH with urolithiasis in 15.1% patients with urinary system infections(USI) – in 38.5%, with anomalies of the urinary system – 27,2% children with neurogenic disorders of urination – at 9.2 percent. The clinical picture of the disease prevailed dysuric disorders (48,5%) and moderately pronounced edema syndrome (45,6%). In the urinary sediment of children with hypercalciuria, the most frequently recorded crystalluria (31,8%), microhematuria (19,2%) and leukocyturia (13.8%). CONCLUSION. Idiopathic hypercalciuria in children is often combined with such pathological conditions as USI, neurogenic disorders of urination, abnormalities of the urinary system and it is the cause of the development of the urolithiasis already in childhood.
About the Authors
N. M. Mikheeva
Altai State Medical University
Russian Federation
Russian Federation
MD, PhD, DMedSci.
656038 Russia, Barnaul, Lenin Avenue, 40, Altai State Medical University Department of propaedeutics of children’s diseases, KMedSei. Phone: (3852) 366-179
G. I. Vykhodtseva
Altai State Medical University
Russian Federation
Russian Federation
Prof., MD, PhD, DMedSci.
656038 Russia, Barnaul, Lenin Avenue, 40, Altai State Medical University Department of Pediatrics with course of postgraduate education, DMedSei. Phone: (3852) 366-179
Ya. F. Zverev
Altai State Medical University
Russian Federation
Russian Federation
Prof., DMedSci
Russia 656038, Barnaul, Leninast., 40 Altai State Medical University Department of Pharmacology. Phone: (3852) 619-182
Yu. F. Lobanov
Altai State Medical University
Russian Federation
Russian Federation
Prof., DMedSci.
Russia 656000, Barnaul, Leninast., 40 Altai State Medical University Department of Propudeutics of Childrens Diseases. Phone: (3852) 619-182
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Review
For citations:
Mikheeva N.M., Vykhodtseva G.I., Zverev Ya.F., Lobanov Yu.F. FEATURES OF THE COURSE OF IDIOPATHIC HYPERCALCIURIA IN CHILDREN. ANALYSIS OF CLINICAL AND LABORATORY MANIFESTATIONS. Nephrology (Saint-Petersburg). 2017;21(4):68-72. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-4-68-72
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