DRUG THERAPY FOR PATIENTS WITH CHRONIC KIDNEY DISEASE: IS THERE A PLACE FOR DOUBLE NEPRILYSIN AND AT1-ANGIOTENSIN RECEPTOR INHIBITOR LCZ696 (SACUBITRIL/VALSARTAN)?
https://doi.org/10.24884/1561-6274-2018-22-2-59-67
Abstract
The review presents data on the involvement of the system of circulating and renal tissue natriuretic peptides in the mechanism that supports water-salt homeostasis and protects the kidney from damage of various etiologies, as well as the results obtained in assessing the clinical efficacy and safety of a new drug from vasopeptidase inhibitors LCZ696 (sacubitryl/valsartan) in patients with chronic kidney disease.
About the Authors
O. B. Kuzmin
Orenburg State Medical University
Russian Federation
Russian Federation
Oleg B Kuzmin, MD, PhD, DMedSci, Prof., Department of Pharmacology
460000 Russia, Orenburg, Park st., 7.
V. V. Zhezha
Orenburg State Medical University
Russian Federation
Vladislav V. Zhezha, Department of Pharmacology
Russian Federation
Vladislav V. Zhezha, Department of Pharmacology
460000 Russia, Orenburg, Park st., 7.
V. V. Belaynin
Orenburg State Medical University
Russian Federation
Russian Federation
Vitaly V. Belyanin, Department of Pharmacology
460000 Russia, Orenburg, Park st., 7.
L. N. Landar
Orenburg State Medical University
Russian Federation
Russian Federation
Larisa N. Landar, Department of Pharmacology
460000 Russia, Orenburg, Park st., 7.
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Review
For citations:
Kuzmin O.B., Zhezha V.V., Belaynin V.V., Landar L.N. DRUG THERAPY FOR PATIENTS WITH CHRONIC KIDNEY DISEASE: IS THERE A PLACE FOR DOUBLE NEPRILYSIN AND AT1-ANGIOTENSIN RECEPTOR INHIBITOR LCZ696 (SACUBITRIL/VALSARTAN)? Nephrology (Saint-Petersburg). 2018;22(2):59-67. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-2-59-67
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