THE ROLE OF ACYL GHRELIN IN PROGRESS OF MALNUTRITION IN PATIENTS WITH END STAGE KIDNEY FAILURE RECEIVING PROGRAM HEMODIALISIS

ABSTRACT AIM OF RESEARCH: To study interrelation between acyl-ghrelin concentration in blood serum and general signs of malnutrition in patients receiving program hemodialysis. PATIENTS AND METHODS. 102 patients with V stage chronic kidney disease receiving program hemodialysis were examined, among them 52 male and 50 female, average age 49,0 ± 7,7. All patients was performed fiberoptic gastroduodenoscopy (FGDS) with biopsy of antral department and gastric corpus. Material was used for detection of Helicobacter pylori – contamination, study of cytological and histological pattern of gastric mucosa. Patients state and compositional analysis of patients body were evaluated by method of complex nutritional evaluation, caliperometry, bioelectrical impedance analysis. Acyl-ghrelin level detection in blood serum was performed by enzyme-linked immunosorbent assay (ELISA) using commercial kits (Spi-bio, Montigny le Bretonneux, France). RESULTS. During undertaken study authentic decrease of blood serum acyl ghrelin level was demonstrated at augmentation of intensity of different gastric departments mucous coat atrophic changes. Also demonstrated decrease of blood serum acyl ghrelin concentration if gastric mucosa is bacterized by Нelicobacter pylori. Authentic positive correlation between blood serum acyl ghrelin level and general signs of nutritional status of patients is revealed. CONCLUSION. Blood serum acyl ghrelin level decrease can be one of pathogenetic factors taking part in development of malnutrition in patients on program hemodialysis.

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