ALGORITHM FOR DIAGNOSIS OF AGE ANDROGEN DEFICIENCY IN MEN WITH URINATION DISORDERS

Abstract

THE AIM of the study was to develop a diagnostic algorithm of the age androgen deficiency (VAD) in men with disorders of urination based on the complex relationships between clinical and biochemical criteria of androgen saturation of the male body. PATIENTS AND METHODS. The study is based on the results of the study 100 men with urinary disorders caused by benign prostatic hyperplasia, prostatitis and chronic abacterial their combination (64 (64%), 20 (20%) and 16 (16%) patients, respectively). The average age of patients was 58,5 ± 1,2 years. All patients underwent complex clinical, laboratory and instrumental methods of examination, questioning the questionnaire AMS, determination of blood levels of total testosterone binding globulin sex steroids, the calculation of free and bioavailable testosterone. RESULTS. It was found based on the evaluation of responses AMS survey that most complaints have been expressed to reduce the frequency and power of sexual relations, reducing the number of morning erections, and increased sweating. The level of free testosterone most closely match the clinical symptoms of androgen deficiency, but the reliability of the relationship between testosterone concentration and the amount of AMS score was below the threshold. Sensitivity and specificity of the questionnaire in the diagnosis of AMS LOH confirmed by measuring blood levels of free testosterone were 88% and 19% respectively. There was found significant correlation between testosterone concentration of the blood and the number of points obtained in the responses to four survey questions. It was developed an algorithm for diagnosis of age-androgen deficiency in patients with disorders of urination based on the survey and clinical findings. CONCLUSION. The proposed algorithm can improve the diagnosis and to clarify the indications for hormone replacement therapy in men with androgen deficiency age.