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NEPHROTIC SYNDROME IN THE FRAMES OF POLYCYSTIC KIDNEY DISEASE: DESCRIPTION OF TWO CASES

https://doi.org/10.24884/1561-6274-2011-15-2-84-88

Abstract

Two cases of nephrotic syndrome in patients suffering from autosomaldominant polycystic kidney disease is described. During nephrobiopsy were the following morphological diagnoses were stated: IgA-nephropathy and membranous nephropathy. Isolated appointment of ACE inhibitor did not lead to a reduction in proteinuria, but its combination with methyl-prednisolone and cytotoxic drugs for different periods allowed significantly reduce proteinuria and stabilize renal function. Our cases showed the appropriateness of the nephrobiopsy in patients with polycystic kidney disease and nephrotic syndrome in order to determine further management treatment and prevention of progression of renal failure.

About the Authors

K. S. KOMISSAROV
Белорусская медицинская академия последипломного образования
Belarus


M. V. DMITRIEVA
1-ая городская клиническая больница г. Минска
Belarus


t. N. TSVIRKO
1-ая городская клиническая больница г. Минска
Belarus


K. S. EFREMOV
1-ая городская клиническая больница г. Минска
Belarus


V. S. PILOTOVICH
Белорусская медицинская академия последипломного образования
Belarus


References

1. Wilson PD. Polycystic kidney disease. N Engl J Med 2004; 350: 151-164

2. Chapman AB, Johnson AM, Gabrow PA et al. Overt proteinuria and microalbuminuria in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995; 6: 1349-1354

3. Contreras G, Mercado A, Pardo V et al. Nephrotic syndrome in autosomal dominant polycystic kidney disease. J Am Soc Nephrol 1995; 6: 1354-1359

4. Chapman AB, Johnson AM, Kaehny WD, Schrier R, Gabow P. Glomerular hyperfiltration: an early manifestation of autosomal dominant polycystic kidney disease. Kidney Int 1989; 35: 203 A.

5. D'Agati V. The many masks of focal segmental glomerulosclerosis. Kidney Int 1994; 46: 1223-1241

6. Dalgaard OZ. Bilateral polycystic disease of the kidney. A follow-up of two hundred and eighty-four patients and their families. Acta Med Scand 1957; 328: 1-255

7. Kida H, Nakamoto Y, Shinoda A. Case of polycystic kidney with nephritic syndrome. Naika Int Med 1972; 29: 168-172

8. Hiura T, Yamazaki H, Saeki T et al. Nephrotic y syndrome and Ig nephropathy in polycystic kidney disease. Clin Exp Nephrol 2006; 10: 136-139

9. Wan RK, Kipgen D, Morris S, Rodger RSC. A rare cause of nephrotic syndrome in autosomal-dominant polycystic kidney disease. Nephrol Dial Transplant 2009; 2: 136-138

10. Glassock RJ, Adler SG, Ward HJ, Cohen AH. Primary glomerular disease. In: Brenner BM., Rector FC, eds. The kidney. 4th Ed. Baltimore, Williams & Wilkins; 1991: 1182-1279

11. Olson JL, de Urdaneta AG, Heptinstall RH. Glomerular hyalynosis and its relation to hyperfiltration. Lab Invest 1985; 52: 387-398

12. Brenner BM. Hemodinamically mediated glomerular injury and the progressive nature of kidney disease. Kidney Int 1983; 23: 647-655

13. Panisello JM, Martinez-Vea A, Garcia C, Carrera M et al. Ig A nephropathy and polycystic kidney disease. Am J Nephrol 1988; 8: 477-478

14. Ponticelli C, Passerini P. Can prognostic factors assist therapeutic decisions in idiopathic membranous nephropathy? J Nephrol 2010; 23 (2): 156-163

15. Abe R, Yamaguchi K, Igarashi N, Fukuda Y et al. A case of polycystic kidney associated with membranous nephropathy. Jin to Touseki 1985; 19: 389-392

16. Shikata K, Makino H, Ota Z. A membranous nephropathy associated with adult polycystic kidney disease. Clin Nephrol 1991; 36: 223-227

17. Oguro T, Yasuoka N, Tanioka K, Itahara T et al. A case of nephrotic syndrome and membranous nephropathy in polycystic kidney disease (abstract). Jpn J Nephrol 1989; 31: 1329

18. Adu D, Gwyn WD, Taube D et al. Late onset systemic lupus erythematosis and lupus-like disease in patients with apparent idiopathic glomerulonephritis. Q J Med 1983; 52: 471-487


Review

For citations:


KOMISSAROV K.S., DMITRIEVA M.V., TSVIRKO t.N., EFREMOV K.S., PILOTOVICH V.S. NEPHROTIC SYNDROME IN THE FRAMES OF POLYCYSTIC KIDNEY DISEASE: DESCRIPTION OF TWO CASES. Nephrology (Saint-Petersburg). 2011;15(2):84-88. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-2-84-88

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)