MORPHOLOGIC ASPECTS OF NONSTEROIDAL ANTIFLAMMATORY DRUGS NEPHROTOXIC EFFECT

THE AIM. The aim of research to study of kidney morfologic injury pattern developing at paracetamol toxic dose effect at subchronic administration and also studying of potential protective effect of CysLT1 receptor blocker – montelukast in respect of paracetamol nephrotoxicty. MATEIALS AND METHODS. Experimental study was carried out on 30 outbred male rats males divided into three groups. First group (10 rats) received paracetamol orally by gastric tube in dose 100 mg/kg, which is equivalent nearly 30-50% of LD50 of this drug. Control group (10 rats) received orally single dose 1 ml of isotonic saline solution. Third group received orally peptide-leukotriene receptor blocker montelukast in dose 40 mg/kg and 1 hour later – paracetamol in dose 1000 mg/kg. Histological research was carried out on 5 μm slices. RESULTS. It is shown that administration of paracetamol at subtherapeutic had nephrotoxic effect on all components of kidney tissue and causes development of excretory necronephrosis with glomerulitis. Pre-administration of antileukotriene medication (montelukast) have protective effect. CONCLUSION. Signs of rat kidneys parenchyma and stroma damage which occur during paracetamol reflect increasing structural functional degradation of organ with risk of kidney failure development. CysLT1 receptor blockers used during experiment reduce and neutralize nephrotoxic effect of cyclooxygenase 2 ingibitors.

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