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АУТОВОСПАЛИТЕЛЬНЫЕ ЗАБОЛЕВАНИЯ: ОБЩЕЕ ПОНЯТИЕ, МЕХАНИЗМЫ РАЗВИТИЯ, КЛИНИЧЕСКАЯ КАРТИНА, ПОДХОДЫ К ЛЕЧЕНИЮ

https://doi.org/10.24884/1561-6274-2012-16-2-49-63

Аннотация

В последние годы в медицинской научной литературе появилось новое понятие «системные аутовоспалительные заболевания». В отличие от аутоиммунных заболеваний в инициации аутовоспалительных болезней играют роль, главным образом, генетически детерминированные реакции иммунитета и воспаления, а не механизмы, связанные с антигениндуцированным синтезом антител или активацией Т-лимфоцитов. Группа аутовоспалительных заболеваний включает в себя семейные периодические лихорадки (периодическую болезнь, синдром Макла–Уэллса и др.), наиболее частым осложнением которых является вторичный АА-амилоидоз. Молекулярно-генетические исследования показали, что важнейшим механизмом аутовоспаления является нейтрофильное воспаление, ассоциированное с гиперпродукцией интерлейкина-1. Ведущим пусковым механизмом нейтрофильного воспаления является образование макромолекулярного комплекса – криопириновой инфламмасомы, которая имеет важное значение в инициации воспаления не только при семейных периодических лихорадках, но и при ряде широко распространенных воспалительных заболеваний (подагра, ХОБЛ и др.). В этой связи криопириновая инфламмасома может рассматриваться как один из универсальных механизмов нейтрофильного воспаления. Хронические аутовоспалительные заболевания создают персистирующий воспалительный фон и способствуют активации иммунных реакций с возможным развитием классических аутоиммунных заболеваний, что наглядно показывают представленные клинические наблюдения.

Об авторах

В. В. Рамеев
Первый МГМУ им.И.М.Сеченова
Россия

Кафедра нефрологии, внутренних и профессиональных заболеваний им.Е.М.Тареева 

Тел.: 89104936138



Л. В. Козловская
Первый МГМУ им.И.М.Сеченова
Россия
Кафедра нефрологии, внутренних и профессиональных заболеваний им.Е.М.Тареева


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Рецензия

Для цитирования:


Рамеев В.В., Козловская Л.В. АУТОВОСПАЛИТЕЛЬНЫЕ ЗАБОЛЕВАНИЯ: ОБЩЕЕ ПОНЯТИЕ, МЕХАНИЗМЫ РАЗВИТИЯ, КЛИНИЧЕСКАЯ КАРТИНА, ПОДХОДЫ К ЛЕЧЕНИЮ. Нефрология. 2012;16(2):49-63. https://doi.org/10.24884/1561-6274-2012-16-2-49-63

For citation:


Rameev V.V., Kozlovskaya L.V. AUTOINFLAMMATORY DISEASES: GENERAL IDEA, DEVELOPMENT MECHANISMS, CLINICAL PRESENTATION, TREATMENT. Nephrology (Saint-Petersburg). 2012;16(2):49-63. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-2-49-63

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