BIOMARKERS IN THE DIAGNOSIS OF ACUTE KIDNEY INJURY. COMMUNICATION II
Abstract
In the past few years increasing attention attended to the possibility of using biomarkers in the diagnosis of acute kidney injury because of disadvantages of the traditional parameters such as serum creatinine and urea, diuresis measurement, which on the one hand depends on a number of extrarenal factors, on the other - they change occurs in the later, irreversible stages of renal tissue damage. This article analyzes the possibility of using a number of markers in the early diagnosis of different types of AKI. Second part of work discusses diagnostic value of such biomarkers as low molecular weight proteins (alfa1-microglobuline, beta2-microglobuline etc.), intracellular enzymes, micro-RNA as well as the ability of using several markers in one panel.
About the Authors
Ia. Iu. Proletov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
E. S. Saganova
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
A. V. Smirnov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
R. V. Zver'kov
Pavlov First Saint Petersburg State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Proletov I.I., Saganova E.S., Smirnov A.V., Zver'kov R.V. BIOMARKERS IN THE DIAGNOSIS OF ACUTE KIDNEY INJURY. COMMUNICATION II. Nephrology (Saint-Petersburg). 2014;18(6):51-58. (In Russ.)
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