SIGNIFICANCE OF SEASONAL FACTOR IN EVALUATION OF VITAMIN D STATUS AT PATIENTS WITH EARLY STAGES OF CHRONIC KIDNEY DISEASE
https://doi.org/10.24884/1561-6274-2012-16-2-79-83
Abstract
AIM OF RESEARCH: to define the esimate of seasonal factor on vitamin D (VD) status in patients with early stages of chronic kidney disease (CKD). PATIENTS AND METHODS. There were examined 94 patients with CKD of 1-4 stage, male/female – 45/49, 60,1±12,6 years mainly with diabetic nephropathy (91,2%). Besides usual factors by immunoenzyme method were estimated 25(OH)D and 1,25(OH)2D. RESULTS. Defficiency of 25(OH)D (level is lower 30 nM/l) was diagnosed at 14,9% of patients, insufficiency (30-75 nM/l) – at 55,4% and optimal value (higher than 75 nM/l) – at 29,7%. In 63,8% of cases insufficiency of 1,25(OH)2D was defined (concentration in serum lower than 53nM/l). In autumn level of 25(OH)D (n=30) was higher than in spring (n=64, p=0,002). According to data of multiple regression analysis was defined tendention of value seasonal variations of 1,25(OH)2D (p=0,09) due to escurtion of 25(OH)D. CONCLUSION. Insufficiency and defficiency of 25(OH)D are regular at patients with chronic kidney disease of 1-4 stage. Level of 25(OH)D have serious seasonal variations which provide some seasonal variations of 1,25(OH)2D concentration.
About the Authors
M. M. VolkovRussian Federation
H. Rafrafi
Russian Federation
A. V. Smirnov
Научно-исследовательский институт нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
Volkov M.M., Rafrafi H., Smirnov A.V. SIGNIFICANCE OF SEASONAL FACTOR IN EVALUATION OF VITAMIN D STATUS AT PATIENTS WITH EARLY STAGES OF CHRONIC KIDNEY DISEASE. Nephrology (Saint-Petersburg). 2012;16(2):79-83. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-2-79-83
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