ANALYSIS OF RELATIONS BETWEEN ERYTHROCYTIC MEMBRANE RESISTANCE INDICATORS AND CLINICO-LABORATORY INDICATORS AT PATIENTS WHO RECEIVE REGULAR HEMODIALYSIS

Abstract

Here presented data about change of status in bilipidic membrane layer at long term dialysis therapy with demonstration of internal relations between most informative indicators received at patients assessment as a result of long-term studying of erythrocytes membrane quality at patients with hemodialysis. It is established that condition of plasmatic erythrocytic membranes of patients with chronic hemodialysis alter considerably according to treatment term. Most significant aberrations are noted at early terms of therapy – at duration of hemodialysis from 1 to 3,8 years, which occurs in most evident destabilization of membranous structures. At longer terms of hemodialysis therapy resistance of erythrocytes to external actions of canaloformer practically doesn’t differ from values typical for people without renal pathology. Factorial analysis of ensemble which associates all clinical, biochemical and biophysical factors of patients with chronic hemodialysis was carried out. It is shown that the general component which mainly contributes into structure of general assembly of factors is only values of integral normalized potassium output at only nystatin effect at erythrocytes of hemodialysis patients. According to received data the conclusion is that membranoprotective therapy must become integral and obligatory part of preventive therapy at all stages of CKD treatment.