PATHOGENETIC PROSTATITIS MODEL IN EXPERIMENT AT SMALL LABORATORY ANIMALS

AIM OF RESEARCH. Pathogenic prostatitis model development based on inflammation initial phase induction – alteration (injury) of tissues and cells with secretion of mediators by pathological prostate venous hyperemia. MATERIALS AND METHODS. Venous flow caused by one dose delivery of 1 ml cocktail of turpentine oil (metaxylene or orthoxylene) and 10% Dimexidum solution in the ratio of 1:4 per rectum in rats via special atraumatic semihard catheter of 25 mm length (distance between anus and prostate at rats). Research was carried out in 2 sets of tests on 98 white outbread rats males with weight 180±30 g. First set (46 rats) is dedicated to acute orostatitis, second (52 rats) – to chronic prostatitis. In both sets rats of 1 group were intact. To rats of 2-nd and 3-rd groups 0.25 ml Dimexidum or 0.25 ml turpentine were infused per rectum. In the same way in both sets 1 ml of cocktail of Dimexidum and turpentine was infused to rats of 4 group per rectum. RESULTS. Results were estimated after 10 days (in first set) and 35 days (in second set). Rats were taken out of test with guillotine. Microscopic research revealed presence of strongly marked acute (in 1-st set) and chronic (in 2-nd set) inflammation in prostate at rats of test groups. Thus specific changes of epithelium and stroma were associated with significant changes of venous bed, including venules microthrombosis. More than in 57% of cases chronic inflammation was associated with chronic gonecystitis and almost in 30% of cases also developed chronic proctitis. CONCLUSION. The study confirms leading role of pathological venous hyperemia in pathogenesis both acute and chronic prostatitis. Prostatitis caused in this way is a typical example of nonspecific inflammatory response. Development of prostatitis is associated with gonecystitis and can complicate with associated chronic proctitis. Results of research imphasize the need of pathogenetic action medicines in complex treatment of both acute and chronic prostatitis.

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