GOUT AND KIDNEYS: FEATURES AT ELDERLY
https://doi.org/10.24884/1561-6274-2012-16-3/1-114-116
Abstract
Gout is a systemic disease at which monosodium urate cristals deposit in different organs and tissues and in patients with hyperuricemia develops inflammation caused by environmental and/or genetic factors. Nowadays a lot of epidemiological data about worldwide hyperuricemia increasing is accumulated. It is considered, that generally men suffer from gout, but today equal morbidity rate occurs in both men and women. Last researches showed increasing growing prevalence of gout especially in geriatric patients.
About the Authors
A. L. AryevRussian Federation
N. A. Kunitskaya
Russian Federation
M. A. Andrainova
Russian Federation
References
1. Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase. Biochem Pharmacol 2005;70(3):343–354
2. Kanellis J, Kang DH. Uric acid as a mediator of endothelial dysfunction, inflammation, and vascular disease. Semin Nephrol 2005;25(1):39–42
3. Kang DH, Nakagawa T. Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease. Semin Nephrol 2005; 25(1):43–49
4. Pascual E, Ordóñez S. Orderly arrayed deposit of urate crystals in gout suggest epitaxial formation. Ann Rheum Dis 1998; 57: 255-259
5. Simkin P A. The pathogenesis of podagra. Ann Intern Med 1977; 86: 230–233
6. Watanabe S, Kang DH, Feng L et al. Uric acid, hominoid evolution, and the pathogenesis of salt sensitivity. Hypertension 2002; 40: 355–360
7. Roch-Ramel F, Guisan B. Renal transport of urate in humans. News Physiol Sci 1999; 14: 80–84
8. Maesaka J K, Fishbane S. Regulation of renal urate excretion: a critical review. Am J Kidney Dis 1998; 32: 917–933
9. Takahashi T, Tsuchida S, Oyamada T, et al. Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese. Pediatr Nephrol 2005; 20(5):576–578
10. Enomoto A, Endou H. Roles of organic anion transporters (OATs) and a urate transporter (URAT1) in the pathophysiology of human disease. Clin Exp Nephrol 2005; 91: 95–205
11. Hediger MA, Johnson RJ, Miyazaki H, Endou H. Molecular physiology of urate transport. Physiology (Bethesda) 2005; 20: 125–133
12. Simkin PA. When, why, and how should we quantify the excretion rate of urinary uric acid? J Rheumatol 2001; 28: 1207–1210
13. Tykarski A. Evaluation of renal handling of uric acid in essential hypertension: hyperuricemia related to decreased urate secretion. Nephron 1991; 59: 364–368
14. Ichida K, Hosoyamada M, Kamatani N et al. Age and origin of the G774A mutation in SLC22A12 causing renal hypouricemia in Japanese. Clin Genet 2008;74(3):243–251
15. Perez-Ruiz F, Calabozo M, García-Erauskin G. et al. Renal underexcretion of uric acid is present in patients with apparent high urinary uric acid output. Arthritis Rheum 2002; 47: 610–613
16. WHO World health organization/international society of hypertension (WHO/ISH) hypertension guidelines. Clin Exp Hypertens 2004; 26: 747–752
17. Hagos Y, Stein D, Ugele B, Burckhardt G, Bahn A. Human renal organic anion transporter 4 operates as an asymmetric urate transporter. J Am Soc Nephrol 2007; 18(2):430–439
18. Eraly SA et al. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics 2008;33(2):180–192
19. Waller PC, Ramsay LE. Predicting acute gout in diuretictreated hypertensive patients. J Hum Hypertens 1989; 3: 457–461
20. Steele TH, Oppenheimer S. Factors affecting urate excretion following diuretic administration in man. Am J Med 1969; 47: 564–574
21. Suki WN, Hull AR, Rector FC et al. Mechanism of the effect of the thiazide diuretics on calcium and uric acid. J Clin Invest 1967; 461: 121-124
22. Quarantino CP, Di Sciacio N, Rucci C, Ciaglia P, Giacomello A. The normal range of serum urate levels and of fractional urate excretion. Adv Exp Med Biol 1994; 370: 91–93
23. Tinahones JF, Pérez Lindón G, Soriguer FJ et al Dietary alterations in plasma very low density lipoprotein levels modify renal excretion of urates in hyperuricemic-hypertriglyceridemic patients. J Clin Endocrinol Metab 1997; 82: 1188–1191
24. Lin JL, Yu CC, Lin-Tan DT, Ho HH. Lead chelation therapy and urate excretion in patients with chronic renal diseases and gout. Kidney Int 2001; 60: 266–271
25. Lin HY, Rocher LL, McQuilan MA et al. Cyclosporine induced hyperuricemia and gout. N Engl J Med 1989; 321: 287–292
26. Urano W, Yamanaka H, Tsutani H et al. The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis. J Rheumatol 2002; 29: 1950–1953
27. Simkin P A, Hoover PL, Paxson CS, Wilson WF. Uric acid excretion: quantitative assessment from spot, midmorning serum and urine samples. Ann Intern Med 1979; 91: 44–47
28. So A. Developments in the scientific and clinical understanding of gout. Arthritis Res Ther 2008;10(5): 221-229
29. Scott JT, Higgens CS. Diuretic induced gout: a multifactorial condition. Ann Rheum Dis 1992; 51: 259–261
30. Ochiai ME., Barreto ACP, Oliveira MT et al. Uric acid renal excretion and renal insufficiency in decompensated severe heart failure. Eur J Heart Fail 2005; 7: 468–474
31. Garbagnati E, Boschetti M. Uric acid homeostasis in lean and obese girls during pubertal development. Metabolism 1994; 43: 819–821
32. Janssens HJEM, van de Lisdonk EH, Janssens M et al Gout, not induced by diuretics? A case-control study from primary care. Ann Rheum Dis 2006; 65: 1080–1083
33. Facchini F, Chen Y-D, Hollenbeck CB, Reaven GM. Relationship between resistance to insulin-mediated glucose uptake, urinary uric acid clearance, and plasma uric acid concentration. JAMA 1991; 266: 3008–3011
34. Bairaktari ET, Kakafika AI, Pritsivelis N et al. Hypouricemia in individuals admitted to an inpatient hospital-based facility. Am J Kidney Dis 2003; 41: 1225–1232
35. Hopkinson N, Doherty M. In patients with chronic cardiac failure who have diuretic induced gout, are certain diuretics less prone at causing problems? Br J Rheumatol 1991; 30: 225-227
36. Caspi D, Lubart E, Graff E et al The effect of mini-dose aspirin on renal function and uric acid handling in elderly patients. Arthritis Rheum 2000; 43: 103–108
Review
For citations:
Aryev A.L., Kunitskaya N.A., Andrainova M.A. GOUT AND KIDNEYS: FEATURES AT ELDERLY. Nephrology (Saint-Petersburg). 2012;16(3/1):114-116. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-3/1-114-116