RETROSPECTIVE ESTIMATION OF CHRONIC GLOMERULONEPHRITIS STARTING IN CHILDHOOD

Abstract

THE AIM of the investigation was to analyze the course of morphologically confirmed forms of chronic glomerulonephritis (CGN) from its debut in childhood and adolescence to adult age, to assess the effects of clinical-laboratory symptoms of CGN debut on its further course. MATERIALS AND METHODS. The course of the disease was analyzed in 110 patients with a morphologically verified form of CGN with debut in childhood. The investigation took in consideration the premorbid background of the disease debut, hereditary factor, clinical and laboratory data of the medical documentation of the patients concerned with the course of the disease at its different stages. The maximum period of observations was 42 years. RESULTS. In the morphological structure of CGN prevailing was the mesangial-proliferative form (50.9%) and the lipoid nephrosis considered to be characteristic of the child age was found but in 10.0 % of patients. In 71 patients (65.6%) persistent arterial hypertension developed, in 39 (35.5%) patients CGN was diagnosed, lethal outcome took place in 10 patients (9.1%). No reliable influence of the morphological form on the course and outcome of CGN was revealed. However there was a correlation between the clinical-laboratory indices of the CGN debut and the appearance of persistent arterial hypertension, continuous recurrences of the disease, development of CGN. CONCLUSION. The investigation has shown an interrelation between the clinical-laboratory symptoms of the CGN debut and the character of the further course of the disease. The early predictors of the unfavorable development of CGN were also established.