PROCALCITONIN IN URINE – AS A MARKER OF RENAL TISSUE SEVERE DAMAGE IN CHILDREN WITH VESICOURETERAL REFLUX
https://doi.org/10.24884/1561-6274-2012-16-4-69-74
Abstract
THE AIM. To evaluate the clinical relevance of procalcitonin (PCT) determination in urine in children with vesicoureteral reflux (VUR) and reflux nephropathy (RP). MATERIALS AND METHODS. 25 children aged 6 to 10 years (average age 6,34±4,67) with urinary tract infection (UTI), including 17 girls (68%) and 8 boys were examined. Diagnosis verification was carried out on the basis of anamnesis data and uronephrological patient examination. VUR I degree was diagnosed in 2 children (8%), VUR II degree – in 7 (28%), VUR III degree – in 3 (12%), VUR IV-V degree – in 13 children (52%). Depending on existence and severity of RP under results of the DMSA-scan all children were divided into 2 groups: 1 group – 6 (24%) children with VUR without sclerosis focuses, 2nd group – 19 children with RP, including 11 children with I-II degree of RP (type A and B) and 8 patients with III-IV degree of PN (type C and D). All children included in research had no UIT at PCT and DMSA-scan. PCT was inspected in first void urine by immunoassay (Brachms PCT-Q method). RESULTS. It is established that urine PCT excretion level in children with VUR reflects existence and intensity of RP. The highest PCT level in urine was observed in children with RP III-IV degree and was practically 6 times higher than in children without RP according to DMSA-scan data. CONCLUSION. Findings allow to recommend PCT research in urine as an additional noninvasive marker of renal parenchyma injury and also, possibly, for diagnosis latent inflammation in kidney parenchyma at VUR.
About the Authors
N. M. Zaikova
Научно-исследовательский институт охраны материнства и детства
Russian Federation
Russian Federation
V. V. Dlin
НИИ педиатрии и детской хирургии
Russian Federation
Russian Federation
L. Sinitsina
Научно-исследовательский институт охраны материнства и детства
Russian Federation
Russian Federation
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Review
For citations:
Zaikova N.M., Dlin V.V., Sinitsina L. PROCALCITONIN IN URINE – AS A MARKER OF RENAL TISSUE SEVERE DAMAGE IN CHILDREN WITH VESICOURETERAL REFLUX. Nephrology (Saint-Petersburg). 2012;16(4):69-74. (In Russ.) https://doi.org/10.24884/1561-6274-2012-16-4-69-74
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