РОЛЬ СИСТЕМНОГО И ЛОКАЛЬНОГО ВОСПАЛЕНИЯ В РАЗВИТИИ ДИАБЕТИЧЕСКОЙ НЕФРОПАТИИ
Аннотация
В статье представлен анализ современных данных о роли системного и локального воспаления в развитии диабетической нефропатии. Описаны различные аспекты влияния на почки провоспалительных цитокинов: фактора некроза опухолей-α, интерлейкина-1, интерлейкина-6, интерлейкина-18. Рассмотрены основные направления патогенетической терапии. Сделаны выводы о необходимости дальнейшего изучения воспалительных механизмов поражения почек при сахарном диабете, а также клинического и прогностического значения маркеров воспаления при диабетической нефропатии
Об авторах
И. Ю. ПЧЕЛИН
Санкт-Петербургский государственный университет
Россия
Кафедра факультетской терапии медицинского факультета
Россия
Кафедра факультетской терапии медицинского факультета
А. Н. ШИШКИН
Санкт-Петербургский государственный университет
Россия
Кафедра факультетской терапии медицинского факультета
Россия
Кафедра факультетской терапии медицинского факультета
О. А. ЛАПТЕВА
Санкт-Петербургский государственный университет
Россия
Кафедра факультетской терапии медицинского факультета
Россия
Кафедра факультетской терапии медицинского факультета
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Для цитирования:
ПЧЕЛИН И.Ю., ШИШКИН А.Н., ЛАПТЕВА О.А. РОЛЬ СИСТЕМНОГО И ЛОКАЛЬНОГО ВОСПАЛЕНИЯ В РАЗВИТИИ ДИАБЕТИЧЕСКОЙ НЕФРОПАТИИ. Нефрология. 2011;15(4):21-26. https://doi.org/10.24884/1561-6274-2011-15-4-21-26
For citation:
PCHELIN I.Y., SHISHKIN A.N., LAPTEVA O.A. THE ROLE OF SYSTEMIC AND LOCAL INFLAMMATION IN DIABETIC NEPHROPATHY. Nephrology (Saint-Petersburg). 2011;15(4):21-26. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-4-21-26
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