BONE MINERAL DENSITY AND PATHOLOGY OF THE HEART VALVE APPARATUS IN PATIENTS ON CHRONIC HEMODIALYSIS
https://doi.org/10.24884/1561-6274-2006-10-4-62-65
Abstract
THE AIM of the work was to determine the character of the relationship between the bone mineral density in different parts of the skeleton and pathology of the valves of the left half of the heart in patients treated by chronic hemodialysis. PATIENTS AND METHODS. Two-energy X-ray absorptiometry of 3 parts of the skeleton assessed by Z-criterion was performed in 58 patients (m/f – 29/29, mean age 49.8 ± 13.3 years) treated by chronic bicarbonate hemodialysis (HD) on average for 74.3 ± 70.1 months. In addition to general clinical and laboratory indices in all the patients USI was performed and in 40 patients - 24 hours’ monitoring of ECG and of arterial pressure. RESULTS. Patients with low bone mineral density (BMD) of the forearm more often had alterations of the mitral valve (infiltration and calcification; F=3.13, p anova = 0.035). CONCLUSION. More pronounced alterations of the mitral valve in patients with low BMD of the forearm appear to be due to general risk factors of the development of these conditions: prolonged hemodialysis therapy and hyperparathyroidism.
About the Authors
M. M. Volkov
Научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова
Russian Federation
Russian Federation
V. A. Dobronravov
Научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. A. Kuznetsov
Научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова
Russian Federation
Russian Federation
E. V. Shevyakova
Научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова
Russian Federation
Russian Federation
Ya. B. Bystrov
Научно-исследовательский институт нефрологии Санкт-Петербургского государственного медицинского университета им. акад. И.П. Павлова
Russian Federation
Russian Federation
References
1. Taal MW, Roe S, Masud T et al. Total hip bone mass predicts survival in chronic hemodialysis patients. Kidney Int 2003;63(3):1116-1120
2. Matsubara K, Suliman ME, Qureshi RT et al. Bone mineral density is a predictor of survival in ESRD patients. Nephrol Dial Transpl 2005; 20 [suppl 5]: v84
3. Wang AY, Wang M, Woo J et al. Cardiac valve calcification as an important predictor for all-cause mortality and cardiovascular mortality in long-term peritoneal dialysis patients: a prospective study. J Am Soc Nephrol 2003;14(1):159-168
4. Calvino J, Garcia R, Pena G et al. Cardiac valve calcification, QT interval and cardiovascular mortality in hemodialysis. Nephrol Dial Transpl 2006; 21 [suppl 4]: iv437
5. Huting J. Mitral valve calcification as an index of left ventricular dysfunction in patients with end-stage renal disease on peritoneal dialysis. Chest 1994;105(2):383-388
6. Ventura JE, Tavella N, Romero C et al. Aortic valve calcification is an independent factor of left ventricular hypertrophy in patients on maintenance haemodialysis. Nephrol Dial Transplant 2002;17(10):1795-1801
7. Ferramosca E, Bellas A, Muntner P et al. Aortic valve calcification as a marker of coronary artery disease in prevalent hemodialysis patients. Nephrol Dial Transpl 2006; 21 [suppl 4]: iv438
8. Mansour J, Harbouche, Shahapuni et al. Vascular calcifications, oral calcium dose and mortality of hemodialysis patients: any causal relationship? Nephrol Dial Transpl 2005; 20 [suppl 5]: v101
9. Maouad B, Harbouche L, Said S et al. Calcium-oral phosphate binder (ca-opb) based treatment of dialysis hyperparathyroidism is not associated with the age-related inverse link between vascular calcification and bone mineral density (bmd). Nephrol Dial Transpl 2005; 20 [suppl 5]:v100
10. Joki N, Hase H, Kishi N et al. Calcaneal osteopenia is a strong predictor for cardiovascular events independent of malnutrition inflammation status in chronic hemodialysis patients. Nephrol Dial Transpl 2005; 20 [suppl 5]: v102
11. Davutoglu V, Yilmaz M, Soydinc S et al. Mitral annular calcification is associated with osteoporosis in women. Am Heart J 2004;147 (6):1113-1116
Review
For citations:
Volkov M.M., Dobronravov V.A., Kuznetsov A.A., Shevyakova E.V., Bystrov Ya.B. BONE MINERAL DENSITY AND PATHOLOGY OF THE HEART VALVE APPARATUS IN PATIENTS ON CHRONIC HEMODIALYSIS. Nephrology (Saint-Petersburg). 2006;10(4):62-65. (In Russ.) https://doi.org/10.24884/1561-6274-2006-10-4-62-65
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