SIGNIFICANCE OF ANNEXIN¬5 IN EVALUATION OF THE DEGREE OF ENDOTHELIAL DYSFUNCTION AT THE PRECLINICAL STAGE OF ATHEROSCLEROSIS IN PATIENTS WITH CHRONIC KIDNEY DISEASE

THE AIM of the investigation was to assess the significance of annexin5 (An5) at the preclinical stage of atherosclerosis in patients with chronic kidney disease. PATIENTS AND METHODS. Under investigation there were 46 patients with CKD without clinical manifestations of atherosclerosis. The parameters of lipidogram, complex intimamedia thickness, endothelial dysfunction and the An5 level were determined. RESULTS. The decreased GFR was followed by an increased An5 level. Its concentration was interconnected with the lipidogram indices. The increased level of annexin5 is accompanied by the most pronounced dysfunction of the endothelium. CONCLUSION. The elevated level of An5 in CKD patients’ blood is especially informative with the absence of clinical symptoms of atherosclerosis and points to the vasomotor form of endothelial dysfunction. The dynamic detection of An 5 can improve the prognostic value of probable cardiovascular problems in patients with CKD.

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