PECULIARITIES OF A COURSE OF CHRONIC GLOMERULONEPHRITIS ASSOCIATED WITH HEPATITIS B VIRUS IN CHILDREN

Abstract

THE AIM of the research was to study the peculiarities of clinical course and biochemical indices of chronic glomemlonephritis associated with hepatitis В virus in children. PATIENTS AND METHODS. Eighteen children aged from 3 to 14 years with chronic glomerulonephritis associated with hepatitis В virus (main group) have been observed. The comparison group consisted of 25 children of the same age without markers of the hepatitis В virus. Most patients in both groups were boys. All the patients had a nephritic form of chronic glomerulonephritis. The clinical symptoms, total blood and urine tests, biochemical and serologic investigations were made. RESULTS. Duration of the disease up to 2 years was noted in most patients of the main group as compared with the comparison group. Clinical signs of the disease were more pronounced in the main group (hepatosplenomegaly, proteinuria, anasarca, ascitis). The previous viral hepatitis was found in case histories of 16% of patients from the main group. The biochemical tests of blood showed reliably high indices of hypercholesterolemia, dysproteinuria, sufficiently increased AlaATT and AapAT activity. CONCLUSION. The hepatitis В virus facilitates the development of severe forms of chronic glomerulonephritis during comparatively short time. Such symptoms as hepatosplenomegaly, proteinuria, anasarca, ascitis, dysproteinuria, hypercholesterolemia are more characteristic of the main group patients.