ROLE OF THE RENIN-ANGIOTENSINE SYSTEM AND NITROGEN OXIDE CYCLE IN PATHOGENESIS OF HYPERTHYROID KIDNEY
https://doi.org/10.24884/1561-6274-2007-11-1-92-99
Abstract
THE AIM of the investigation was to study the role of renin-angiotensine system (RAS) and nitrogen oxide cycle in pathogenesis of hyperthyroid kidney at an early time period of modeling experimental hyperthyroidism in albino rats caused by administration of thyroxin. MATERIAL AND METHODS. Thyroxin (T4) in dose 50 mkg/100 g of body mass was administered into the stomach in 1% starch gel once or during 5 and 7 days. In addition, against the background of a single administration of T4 a solution of ascorbic acid (0.2 mg/100 g b.m.) was given 30 min before water load, or during 24 h from the moment of administration of T4 the rats were given to drink a solution of Captopril (50 mg/l). After 5 days of administration of T4 the rats were also given to drink a solution of Lozartan (10 mg/l) during 24 h from the moment of the last administration of T4. The rats given T4 during 7 days were given L-arginine in dose 2 mg/100 g b.m. a day, or given to drink a solution of sodium nitrite (20 mg/l). The control group rats were given gel not containing T4 administered into the stomach during 7 days. The functioning of the kidneys was studied within 24 h after discontinuation of giving T4 under conditions of 5% water load. RESULTS. It was established that RAS blockers increased the value of creatinin clearance after a single and continuous administration of T4 to rats, but decreased excretion by the rats’ kidneys of endogenous nitrates and protein as well as prevention of endogenous nitrites retention was registered only when the animals were given Lozartan in 5 days after administration of T4. Continuous administration of T4 to rats was followed by weaker effects of NO and redirection of the arginine-dependent way of NO synthesis to the nitrite-reductase one, which is shown by increased level of endogenous nitrites in blood plasma of the rats continuously given T4, the absence of a pronounced correcting nephrotropic effect of exogenous arginin in hyperthyroid animals and growth of creatinin clearance under the influence of exogenous sodium nitrite in the group of hyperthyroid animals. CONCLUSION. The results obtained show a substantial role of RAS and nitrogen oxide cycle in pathogenesis of the development of “hyperthyroid kidney”.
About the Authors
V. N. Zaporozhan
Одесский государственный медицинский университет
Ukraine
Ukraine
S. I. Dolomatov
Одесский государственный медицинский университет
Ukraine
Ukraine
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Review
For citations:
Zaporozhan V.N., Dolomatov S.I. ROLE OF THE RENIN-ANGIOTENSINE SYSTEM AND NITROGEN OXIDE CYCLE IN PATHOGENESIS OF HYPERTHYROID KIDNEY. Nephrology (Saint-Petersburg). 2007;11(1):92-99. (In Russ.) https://doi.org/10.24884/1561-6274-2007-11-1-92-99
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