THE INFLUENCE OF RIFAMPICIN ON THE FUNCTIONAL STATE OF THE WHITE RAT KIDNEYS

Abstract

THE AIM of the investigation was to study effects of rifampicin on the functional state of white rat kidneys under conditions of a single and continuous infusion of the drug. MATERIAL AND METHODS. Aqueous solution of rifampicin was administered into the stomach of mature male rats as a single dose (75 mg/kg of body mass) and during 7 days (30 mg/kg of body mass).The kidney function was determined under conditions of 5% water load in 24 hours after discontinuation of giving the drug. RESULTS. It was found that rifampicin caused a mildly reduced glomerular filtration rate and increased excretion of endogenous nitrates and nitrites independent of the method of introduction. At the same time, a reliably increased rate of excretion of protein by the kidneys was noted but in the group of rats given the drug in a dose 75 mg/kg of b.m. CONCLUSION. It was shown that a single or continuous doses of rifampicin resulted in reliably changed functional state of the kidneys a decreased glomerular filtration rate and increased renal excretion of endogenous nitrates and nitrites. The kidneys were found to respond to the amount of the given drug that might be due to the power of the mechanisms of biotransformation of rifampicin in organism and its renal clearance.