STRUCTURE OF HOMEOSTATIC RENAL FUNCTIONS IN DYSMETABOLIC NEPHROPATHIES IN CHILDREN

Abstract

THE AIM of the work was to study the indices of waterelectrolyte metabolism and stability of urine in children with dismetabolic nephropathies. PATIENTS AND METHODS. The observations were performed in 118 dismetabolic nephropathy children aged from 5 to 16 years. The biochemical methods of the analysis of urine included the following: diurnal urine excretion, urine pH, excretion of ammonia, titrated acidity, concentration and excretion of basic ions (sodium, potassium, inorganic phosphorus, chlorine). Risk of crystallization of urine in relation to the salts of oxalic and uric acids was detected by determining calcium and magnesium ions by the atomadsorption method. The indices of factors of urine stability and calciphylaxis tests, peroxide and polar lipid tests were studied by standard methods developed by E.Yu.Yurieva (1984). RESULTS. Certain components of the structure of tubular dysfunction were determined in children with dismetabolic nephropathies. CONCLUSION. Changes in indices of the functional state of the kidneys, membrane destruction and urine stability factors were revealed which were better expressed in groups of children with metabolic disorders in combination with inflammatory diseases of the kidneys and non infectious pathology of organs of the gastrointestinal tract.