STATE OF LOCAL HEMOSTASIS IN COMPLEX TREATMENT OF EXPERIMENTAL NEPHRITIS

Abstract

THE AIM of the investigation was to study the local system of kidney hemostasis in complex treatment of experimental Mazugi nephritis. MATERIAL AND METHODS. Blood tests were taken from the renal artery and renal vein of 50 rabbits narcotized with ethaminal before and after administration of a complex of drugs (plasma with high content of ATIII, phentolamine, prodectine). Effects of plasma and urine of the animals on a number of indices of coagulogram were studied which included 19 tests determining the state of the coagulating and anticoagulating potentials of the local vascular basin of the kidneys. RESULTS. Plasma with high content of ATIII, phentolamin and prodectin have a positive therapeutic effect reducing the formation in the vascular bed of the kidneys of prothrombinase, elevating the content of anticoagulants, enzymatic and nonenzymatic fibrinolytic compounds. CONCLUSION. Treatment of experimental nephritis with plasma with ATIII as the most important cytoprotector inhibiting C3 complement component, with phentolamine as a blocker of alphaadrenoreceptors and prodectine as a kallikrein inhibitor is substantiated pathogenetically.