HELICOBACTER PYLORIINFECTION IN END-STAGE RENAL DISEASE

THE AIM of the study was to examine how renal dysfunction affected the prevalence of Helicobacter pylori. PATIENTS AND METHODS. We studied 31 patients undergoing long-term dialysis and 28 controls without renal disease. Upper gastrointestinal endoscopy was done in all the patients involved in the study. On endoscopy, biopsy specimens were taken for analysis of H.pylori infection by urease test and culture. RESULTS. The prevalence of antral urease activity was significantly less in patients with renal disease than in the control group (51.6% and 85.7%, p<0.01), although the prevalence of positive culture test in dialysis patients didn’t differ from that of the control group (41,7% and 57.1%). The sensitivity of the urease test to diagnose H.pylori infection was 80.0% in the group of patients with end-stage renal disease and 93.8% in the controls. All isolates from the dialysis patients were susceptible to amoxicillin, furasolidone and tetracycline whereas 3 were resistant to azithromycin, 1 was resistant to clarithromycin and all patients were resistant to metranidazole. All isolates from the control group were susceptible to clarithromycin. CONCLUSION. The prevalence of H.pylori infection was the same in dialysis patients when compared with controls. The sensitivity of the urease test was reduced in patients with end-stage renal disease. The number of clarithromycin-resistant isolates was founf to rise in the group of dialysis patients.

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