CIRCADIAN RHYTHMS OF ARTERIAL PRESSURE AND REMODELLING OF THE HEART IN PATIENTS WITH CHRONIC RENAL FAILURE
https://doi.org/10.24884/1561-6274-2003-7-4-29-33
Abstract
THE AIM ofthe investigation was to estimate the interrelations of circadian rhythms of arterial pressure (AP) with the character of heart remodelling in patients with chronic renal failure (CRF). PATIENTS AND METHODS. Circadian monitoring of AP was performed in 82 patients. In 36 of them echocardiographic investigation was made. The progression rate of CRF wasestimated by the time of doubling the blood creatinin level. RESULTS. Patients with the achieved target level but impaired circadian rhythm of AP had approximately similar progressing of CRF as well as the patients with not achieved target level independent of the circadian rhythm of AP, the rates of progressing of CRF in these patients being substantially higher than those in the group of dippers with the achieved target level of AP. Leftventricle hypertrophy (LVH) was more often observed in patients with not achieved target level of AP (x 2=8.26, p=0.04). In addition, the impaired circadian profile of AP was associated with the greater degree of LVH (τ= -0.25; Z=-2.19; p=0.03). The most often variant of myocardium remodelling among the examined patients was concentric hypertrophy of the Ieftventricle (CHLV), the CHLV being mainly revealed in the group of patients with impaired circadian profile of AP. CONCLUSION. It is in the combination of a sufficient degree of nocturnal decrease of AP (normalization of circadian rhythms) and achieving the target levels of AP that can slow down the rate of progressing CRF. The LVH is associated with higher rates of progressing CRF. The myocardium remodelling in CRF patients is influenced by the diurnal rhythms and level of AR.
About the Authors
N. V. Mosina
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. M. Essaian
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. Sh. Rumyantsev
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
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Review
For citations:
Mosina N.V., Essaian A.M., Rumyantsev A.Sh. CIRCADIAN RHYTHMS OF ARTERIAL PRESSURE AND REMODELLING OF THE HEART IN PATIENTS WITH CHRONIC RENAL FAILURE. Nephrology (Saint-Petersburg). 2003;7(4):29-33. (In Russ.) https://doi.org/10.24884/1561-6274-2003-7-4-29-33
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