EFFECTS OF DIETARY PROTEIN ON THE DEVELOPMENT OF EXPERIMENTAL CHRONIC RENAL FAILURE

THEAIM of the work was to investigate effects of ketosteril and SUPRO 760 found in nutritional ration on the development of experimental chronic renal failure (CRF) in Wistar rats. Amodel of CRF was made by means of a standard two-stage operation (5/ 6 nephrectomy). MATERIALS AND METHODS. Under investigation there were 5 groups of rats: 1. rats with 5/6 nephrectomy (NE) given a standard diet; 2. rats which in two weeks after NEwere given the diet having ketosteril (10% ketosteril + 90% carbohydrate) for the following 6 weeks; 3. rats given the diet containing SUPRO 760 (10% soy protein + 90% carbohydrate)after NE; 4. sham operated rats given the standard diet (control group); 5. sham operated rats given SUPRO 760 (10% soy protein + 90% carbohydrate). RESULTS. Within 8 weeks after NEthe uremic rats were compared with the sham operated controls. The uremic rats (group 1)had elevated urea, cholesterol, phosphorus and reduced total calcium in blood serum as compared to the control. The content of urea, cholesterol, phosphorus in blood serum of rats given the diet with SUPRO 760 or ketosteril was Iowerthan that in group 1, though was higher than the indices of the control groups. Calcium level was not reduced. Arterial pressure was considerably higher in group 1 than in groups 2 and 3. Hypertrophy of the left heart ventricle was less in the rats given SUPRO 760 after NE (group 3) than in groups 1 and 2. CONCLUSION. The investigations performed have revealed positive effects of SUPRO 760 on slowing down the development of experimental CRF and confirmed the possibility to use soy proteins in nutritional ration of neurological patients.

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